Pregnancy in Takayasu Arteritis Patients Exposed to Anti-Tumour Necrosis Factor (Anti-TNF)-α Therapy
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2016, Vol 2, Issue 5
Abstract
Anti-TNF agents, IFX in particular,1 appear safe and effective in rheumatic patients during pregnancy. Here, we described two successful pregnancies of TA patients treated with IFX before conception and until 28 wg. Blood pressure remained optimal and the vascular inflammation/remodelling did not worsen.6 Newborns were healthy. We followed the indication to discontinue IFX during the last trimester6 : This approach seems to be safe for the mother and minimizes fetal exposition to the drug. The risk of infections is low. In our reported cases infections were not observed in postpartum period till one years follow-up of the babies. In infants exposed to infliximab in utero a normal antibody response to standard vaccinations is ensuring in the early childhood.7 Live vaccines are recommended after 6 months of age in infants exposed to anti-TNF in utero.8 To the best of our knowledge, this is the first report describing the use of anti-TNF agents in pregnant TA patients.
Authors and Affiliations
Valentina Canti
Keywords
Related Articles
- EP ID EP553588
- DOI 10.17140/GOROJ-2-122
- Views 176
- Downloads 0
A Novel Contributor to Endometrial Receptivity: Endometrial Microbiota
In the recent years, our knowledge about human reproductive system has increased with the development of assisted reproductive technologies; however, embryo implantation rate is still around 25-30%.1 Embryo implantation...
Developmental Exposure to Endocrine Disrupting Chemicals Alters the Epigenome: Identification of Reprogrammed Targets
Endocrine disruptions induced by environmental toxicants have placed an immense burden on society to properly diagnose, treat and attempt to alleviate symptoms and disease. Environmental exposures during critical periods...
A Randomized Clinical Trial Study of the Effects of Varicocelectomy on Sperm Clinical Analysis and DNA Fragmentation: A Preliminary Data
Varicocele is a disease characterized by abnormal dilatation of the testicular veins within the pampiniform plexus due to difficult blood return in this region. The prevalence of varicocele is 30 to 40% in infertile men,...
Different Uses of Chitosan for Treating Serious Obstetric Hemorrhages
Postpartum hemorrhage is a major cause of maternal death worldwide. Many therapeutic strategies have been developed to reduce maternal morbidity and mortality like oxytocin, prostaglandin, and uterine balloons. A new mem...
Endometriosis Research: Need for a Stem-Cell Based Experimental Model
Endometriosis is a complex disease and not a single phenotype can be delineated in available in vitro models. A comparative analysis of pluripotent stem cells in normal endometrium and endometriosis will give an understa...