Pregnancy in Takayasu Arteritis Patients Exposed to Anti-Tumour Necrosis Factor (Anti-TNF)-α Therapy
Journal Title: Gynecology and Obstetrics Research – Open Journal - Year 2016, Vol 2, Issue 5
Abstract
Anti-TNF agents, IFX in particular,1 appear safe and effective in rheumatic patients during pregnancy. Here, we described two successful pregnancies of TA patients treated with IFX before conception and until 28 wg. Blood pressure remained optimal and the vascular inflammation/remodelling did not worsen.6 Newborns were healthy. We followed the indication to discontinue IFX during the last trimester6 : This approach seems to be safe for the mother and minimizes fetal exposition to the drug. The risk of infections is low. In our reported cases infections were not observed in postpartum period till one years follow-up of the babies. In infants exposed to infliximab in utero a normal antibody response to standard vaccinations is ensuring in the early childhood.7 Live vaccines are recommended after 6 months of age in infants exposed to anti-TNF in utero.8 To the best of our knowledge, this is the first report describing the use of anti-TNF agents in pregnant TA patients.
Authors and Affiliations
Valentina Canti
Keywords
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- EP ID EP553588
- DOI 10.17140/GOROJ-2-122
- Views 187
- Downloads 0
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