Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 4
Abstract
The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis. Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica can play an important role in the prevention of disorders associated with kidney stone formation.
Authors and Affiliations
Kumbhar B. P| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Burli S. C| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Mali S.S., Dongare S. D| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India, Patrekar P. V| Department of Pharmacy, Adarsh Institute of Pharmacy, Vita, Maharashtra, India
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