Preliminary phytochemical and toxicity studies of Oenothera biennis
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 2
Abstract
The present investigation was carried out to evaluate the safety of methanol extract from leaves of Oenothera biennis by determining its potential toxicity after acute and sub acute administration in mice. For the acute study, Oenothera biennis was administrated to mice in single doses given by oral route. General behavior adverse effects and mortality were determined up to7 days. In the Sub acute study, the extract was administered orally at doses of 200 and 400 mg/kg for 28 days to mice Biochemical and hematological parameters were determined at the end of 28 days of daily administration. The studies on sub acute toxicity reveals that no mortalities or evidence of adverse effects have been observed in mice following acute oral administration at the highest dose of 2000mg/kg crude extracts of Oenothera biennis. In sub acute toxicity study daily oral administration of methanol extract 200 and 400 mg/kg body weight of Oenothera biennis for up to 28 days did not result in death or significant changes in body weight, Hematological and Biochemical parameters were done and tabulated. Preliminary photochemical studies of extracts of Oenothera biennis screening of chemical constituents for the presence of Carbohydrates Glycosides Alkaloids Sterols Triterpenoids Proteins Amino Acids Tannins Flavanoids and Fixed Oils were tested.
Authors and Affiliations
S Lakshman, B Asha Jyothi, V Mounica, M Shasidhar, D Rahamthulla, A Ravi Kumar
Keywords
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