Preliminary phytochemical and toxicity studies of Oenothera biennis
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 2
Abstract
The present investigation was carried out to evaluate the safety of methanol extract from leaves of Oenothera biennis by determining its potential toxicity after acute and sub acute administration in mice. For the acute study, Oenothera biennis was administrated to mice in single doses given by oral route. General behavior adverse effects and mortality were determined up to7 days. In the Sub acute study, the extract was administered orally at doses of 200 and 400 mg/kg for 28 days to mice Biochemical and hematological parameters were determined at the end of 28 days of daily administration. The studies on sub acute toxicity reveals that no mortalities or evidence of adverse effects have been observed in mice following acute oral administration at the highest dose of 2000mg/kg crude extracts of Oenothera biennis. In sub acute toxicity study daily oral administration of methanol extract 200 and 400 mg/kg body weight of Oenothera biennis for up to 28 days did not result in death or significant changes in body weight, Hematological and Biochemical parameters were done and tabulated. Preliminary photochemical studies of extracts of Oenothera biennis screening of chemical constituents for the presence of Carbohydrates Glycosides Alkaloids Sterols Triterpenoids Proteins Amino Acids Tannins Flavanoids and Fixed Oils were tested.
Authors and Affiliations
S Lakshman, B Asha Jyothi, V Mounica, M Shasidhar, D Rahamthulla, A Ravi Kumar
Keywords
Related Articles
- EP ID EP33196
- DOI -
- Views 293
- Downloads 0
Sustained release drug delivery system: review
Sustained release dosage forms are designed to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side effects. The basic rationale of sustained relea...
Phytochemical evaluation of Vitex leuocoxylon, vitex negundo and vitex trifolia
In the present study, an attempt was made to investigate phytochemical evaluation of Vitex leuocoxylon, Vitex negundo and Vitex trifolia The crude drug powder extracts of the leaves of the above plants were taken for t...
In vitro propagation of a medicinal important plant Bacopa monnieri from nodal explants
Bacopa monnieri, a traditional Indian medicinal plant with high commercial importance, is used as a neurotonic, immuno modulator, adaptogen transquilizing, memory and learning enhancing, cerebral activator, anti-ulcer,...
FORMULATION AND EVALUATION OF BILAYER TABLET OF CONVENTIONAL RELEASE PARACETAMOL AND MODIFIED RELEASE DICLOFENAC SODIUM
The present study deals with formulation and evaluation of bilayer tablet of paracetamol and diclofenac sodium to provide control over release of drug and to maintain the drug concentration. The major ingredients are p...
Phytochemical evaluation of Saraca indica, Jasminium sambac and Rubia cordifolia
In the present study, an attempt was made to investigate Phytochemical evaluation of roots of Saraca indica, Jasminium sambac and Rubia cordifolia. The crude drug powder extracts of the above plants were taken for the...