Premorbid disorders of pancreatic functional state in children with chronic gastroduodenal pathology
Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 6
Abstract
Background. Secondary pancreatic insufficiency in pediatric practice happens increasingly frequently and can occur at any age, both against the background of nutritional deficiencies, and various inflammatory diseases of the upper parts of the digestive tract. The purpose was to investigate the pancreatic functional state in children with chronic gastroduodenal pathology. Materials and methods. The study was conducted on the basis of the gastroenterology unit of the Chernivtsi Regional Clinical Children’s Hospital during 2013–2018. The basic clinical group consisted of 64 children aged 8–18 years with chronic gastroduodenal pathology: 29 patients had chronic gastritis, 30 persons had chronic gastroduodenitis, 5 people had peptic ulcer. All children underwent general clinical studies, ultrasound of the abdominal organs, fibrogastroduodenoscopy, pH-metry, 3-fold coprologic examination; there were determined the activity of α-amylase, serum lipase, urine diastase, feces elastase (FE-1) concentration in feces, serum C-peptide, blood glucose level, and an oral glucose-tolerant test was performed. Statistical processing of the obtained data was carried out by means of the programs Statistics 6.0. Results. The key manifestations were pain (93.7 %), dyspepsia (90.6 %), astheno-neurotic syndromes (57.8 %), a violation of the motor-evacuation function of the stomach and duodenum as a gastroesophageal and duodenogastric reflux. 35.9 ± 3.7 % of the patients developed the signs of pancreatic lesion: thickening of the tail of the pancreas and ultrasonic hyperechoic, amylorrhea, creatorrhoea, type I and II steatorrhoea, changes in the α-amylase level, FE-1, ‘flat’ curves of glucose tolerance test, that indicated the initial disturbances of carbohydrate metabolism. Median C-peptide for children of the basic group was 1.29 ng/ml (CI 1.11–3.42), for children of the comparison group 0.89 ng/ml (CI 0.23–1.12). The tendency to C-peptide level increasing was registered in 12 over-weighted children. These children have a ‘flat’ glucose test curve, as well as a violation of the exocrine function of pancreas manifested with ultrasonic changes. Conclusions. The revealed changes in the pancreatic functional state in the examined children indicate the need to determine the functional state of the gland and its control in the dynamics of treatment of gastroduodenal pathology.
Authors and Affiliations
T. V. Sorokman, V. G. Ostapchuk
Keywords
Related Articles
- EP ID EP393096
- DOI 10.22141/2224-0551.13.6.2018.143158
- Views 79
- Downloads 0
State of Lipid Peroxidation and Antioxidant Defense System in Newborns Requiring Artificial Lung Ventilation
The article deals with studying indicators of lipid peroxidation (TBA-active products, lipid hydroperoxides, diene conjugates) and antioxidant defense (superoxide dismutase, glutathione peroxidase, vitamins A and E) in t...
The problem of gastroptosis as a manifestation of undifferentiated connective tissue dysplasia in the clinical practice of pediatric gastroenterologist
In the article, the authors describe a clinical case of undifferentiated connective tissue dysplasia in 10- and 15-year-old girls. This pathology is common because it has a lot of clinical, morphological and visceral man...
Dynamics of Heart Rate Variability in Children with Systolic Myocardial Dysfunction Under the Influence of Therapy
The aim of the research was to study the dynamics of changes in heart rate variability in children with myocardial pathology depending on the type of therapy. The study involved 84 children and adolescents of both gender...
Role of Probiotics in Optimizing the Causal Treatment for Acute Bacterial Rhinosinusitis
The article deals with one of the most common ENT diseases — rhinosinusitis, in particular of bacterial origin. The basic principles of diagnosis and treatment of this disease, according to current recommendations (EP3OS...
THE PRIORITY TASKS OF PEDIATRICS EDUCATION AND SCIENCE IN THE HEALTH CARE REFORM
In the article listed the main missions for scientists and educators in the context of reforming the current health care for improving the children’s health. Attention is paid to the introduction of international experie...