PREPARATION AND CHARACTERIZATION OF FAST DISNTEGRATING TABLETS OF HYDRALAZINE HYDROCHLORIDE USING DESIGN OF EXPERIMENT TECHNIQUE
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 1
Abstract
Since the dose accuracy and patient’s compliance are important prerequisites for a long term treatment, there is a demand to develop a dosage form which can overcome difficulty in swallowing, inconvenience in administration while travelling, and increase patient’s acceptability. The present work was undertaken to develop fast disintegrating tablet of Hydralazine hydrochloride which will offer desired characteristics and intended benefits in hypertension. A 32 full-factorial experimental design was constructed to study the effect of type and concentration of superdisintegrant on disintegration time, wetting time and dispersion time. The tablets were prepared by direct compression technique. The ANOVA results confirmed that the studied response variables were strongly dependen on chosen factors (p<0.05). More than 90% of drug from optimized tablet was released within 5 minutes during in-vitro dissolution studies. The short term accelerated stability studies of selected formulation indicated that there was insignificant change in the drug content and percent drug released (p<0.05). It was concluded that FDT of hydralazine hydrochloride were formulated successfully.
Authors and Affiliations
Kaur, R. | Pharmaceutics division, Chandigarh College of Pharmacy, Landran, Mohali, India, Sharma, G. | Pharmaceutics division, Chandigarh College of Pharmacy, Landran, Mohali, India, Nagpal, M. | Pharmaceutics division, Chandigarh College of Pharmacy, Landran, Mohali, India, Sidhu, S. | Pharmaceutics division, Chandigarh College of Pharmacy, Landran, Mohali, India, Jain, U. K. | Chandigarh College of Pharmacy, Landran, Mohali, India, Sharma, M. *| Pharmaceutics division, Chandigarh College of Pharmacy, Landran, Mohali, India
Keywords
Related Articles
- EP ID EP2369
- DOI -
- Views 346
- Downloads 21
COMPARISION OF LEVELS OF PERIODONTOPATHIC BACTERIA BY POLYMERASE CHAIN REACTION IN CHRONIC AND AGGRESSIVE PERIODONTITIS PATIENTS BEFORE AND AFTER NON-SURGICAL THERAPY WITH SUBGINGIVAL ANTIMICROBIAL (BIOTENE) IRRIGATION.
INTRODUCTION: Periodontitis is an inflammatory disease of the supporting tissues of teeth caused by specific group of microorganisms resulting in destruction of periodontal ligament, alveolar bone with pocket formation,...
The key role of Kefir probiotic in enhancement the therapeutic action of mesenchymal stem cells in LPS- induced liver injury
Acute liver injury occurs after intraperitoneal injection of lipopolysaccharide (LPS). The release of pro-inflammatory cytokines and oxidative stress are both important in the pathogenesis of LPS-induced liver injury. Th...
Performance Evaluation of PPI Dendrimer Based Valsartan and Fenofibrate Formulations.
The purpose of this investigation was to evaluate the performance of poly (propylene imine) (PPI) dendrimers, with three different drug concentrations, to be used as drug carriers. Drug–dendrimers complexes were investig...
Biological and Clinical Spectrum of Piceatannol – A Hydroxylated Analogue of Resveratrol: A Phytochemical Review.
Resveratrol (3, 4’, 5-trans-trihydroxystilbene), a naturally occurring stilbene, is considered to have a number of beneficial effects, including anticancer, anti-aethrogenic, anti-oxidative, anti-inflammatory, anti-micro...
Method Development and Validation of Montelukast in Bulk and Pharmaceutical Dosage form by RP-HPLC
The present work describes a simple, precise and accurate HPLC method for estimation of montelukast sodium in bulk and in tablet dosage form. Montelukast sodium is a selective and orally active leukotriene receptor antag...