PREPARATION AND CHARACTERIZATION OF SPRAY DRIED MICROPARTICLE OF CARBAMAZEPINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
Carbamazepine, an antiepileptic drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. Consequently, the aim of this study was to improve the dissolution of Carbamazepine. Microparticle containing Carbamazepine was produced by spray drying using Isopropyl alcohol and water in the ratio of 40:60 (v/v) as solvent system to enhance dissolution rate. The prepared formulations were evaluated for in vitro dissolution and solubility. The prepared drug particles were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Dissolution profile of the spray dried microparticle was compared with pure sample and recrystallized sample. Spray dried microparticle exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the Spray dried microparticle was improved compared with recrystallized and pure sample of Carbamazepine. Consequently, it was believed that spray drying of Carbamazepine is a useful tool to improve dissolution. Hence this spray drying technique can be used for formulation of tablets of Carbamazepine by direct compression with directly compressible tablet excipients.
Authors and Affiliations
Mudit Dixit , Parthasarathi Kulkarni , Akash Johri , Ashwini Kini
Keywords
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