PREPARATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING TERBUTALINE SULPHATE 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2

Abstract

In this study, investigation of an oral colon specific, pulsatile device to achieve time and/or site specific release of terbutaline sulphate, based on chronopharmaceutical consideration. The basic design consists of an insoluble hard gelatin capsule body, filled with ethyl cellulose microcapsules of terbutaline sulphate and sealed with a hydro gel plug. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The terbutaline sulphate microcapsules were prepared in three batches, with Ethyl cellulose and dichloromethane (1:2) by varying drug to polymer ratio and evaluated for drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule. Different hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. Programmable pulsatile, colon-specific release has been achieved from a capsule device over a 2–24 h period, consistent with the demands of chronotherapeutic drug delivery. 

Authors and Affiliations

Krunal Patel , Nabin Karna , Biswajit Biswal , Janki Patel

Keywords

Related Articles

PHYTOCHEMICAL INVESTIGATION OF THE SILK COCOONS OF BOMBYX MORI L.  

Silk cocoons, produced by Bombyx mori L. (Bombicidae) are useful as hypotensive, expectorant, bronchodilator and attenuant drug in traditional medicine. Phytochemical investigation of the ethanolic extract of the cocoons...

 DEVELOPMENT AND IN VITRO[/i] EVALUATION OF TRANSDERMAL PATCHES OF LOVASTATIN AS A ANTILIPIDEMIC DRUG

 In present work was designed to develop suitable transdermal matrix patches of Lovastatin (LS),  using hydroxy propyl methyl cellulose (HPMC) and Eudragit RL 100 with Triethyl citrate as a plasticizer. A 32...

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ATENOLOL AND CHLORTHALIDONE FROM PHARMACEUTICAL FORMULATION 

A reverse phase high performance liquid chromatography (RP HPLC) method was developed and validated for the simultaneous estimation of atenolol and chlorthalidone in marketed formulation. The determination was carried ou...

SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND LINEZOLID IN TABLET DOSAGE FORM 

The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Cefixime Trihydrate and Linezolid in bulk and tablet dosage for...

LEECH ON EXTERNAL THROMBOSED HEMORRHOIDS 

Arshas or hemorrhoids included under the category of Mahagadas as it significantly disturbs the normal proceedings or activities of the body like an enemy. It is a guda gata mamsa vikara occurs in three valis of the ano...

Download PDF file
  • EP ID EP108497
  • DOI -
  • Views 98
  • Downloads 0

How To Cite

Krunal Patel, Nabin Karna, Biswajit Biswal, Janki Patel (2011). PREPARATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING TERBUTALINE SULPHATE . International Research Journal of Pharmacy (IRJP), 2(2), 113-119. https://europub.co.uk/articles/-A-108497