ULTRADEFORMABLE LIPID VESICLE AS A NOVEL DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
Various new technologies have been developed for the transdermal delivery of some important drugs. Transdermal route will always remain a lucrative area for drug delivery.The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. The major barrier in transdermal delivery of drug is the skin intrinsic barrier, the stratum corneum, the outermost envelop of the skin that offers the principal hurdle for diffusion of hydrophilic ionisable bioactives. One of the very recent approaches is the use of ultradeformable carrier system (transfersomes®). Which is composed of phospholipid, surfactant, and water for enhanced transdermal delivery? The transfersomal system was much more efficient at delivering a low and high molecular weight drug to the skin in terms of quantity and depth. The system can be characterized by in vitro for vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm. Transferosome is an ultradeformable vesicle, elastic in nature which can squeeze itself through a pore which is many times smaller than its size owing to its elasticity. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. These drugs find place in different places in the elastic vesicle before they get delivered beneath the skin.
Authors and Affiliations
Ambarish Gautam , S. K. Prajapati , J. P Anand , Ali Akhtar , Aviral
Keywords
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