PREPARATION AND EVALUATION OF CONTROLLED RELEASE DILTIAZEM HCl TABLETS BY USING ETHYL CELLULOSE AND ETHYLENE-VINYL ACETATE POLYMERS AS RETARDANT
Journal Title: International Journal of Pharmacy - Year 2011, Vol 1, Issue 1
Abstract
The aim of this study was to prepare and evaluate controlled release tablets of Diltiazem by a wet granulation method using Ethyl cellulose and Ethylene vinyl acetate as a retardant and chloroform (solvent for the polymer) as granulating fluid. The polymers were used at 2, 5 and 10 % concentrations in the formulae. Diltiazem release from the matrix tablets was slow and spread over a period of 12 h depending on the type of the polymer and its concentration. Based on values of correlation coefficient the drug release was found to be by diffusion mechanism following zero order kinetics. From ‘n’ values, tablets prepared with Ethylene vinyl acetate and ethyl cellulose followed Fickian and non-fickian diffusion mechanisms respectively. Among all the formulations CRF4 exhibited better controlled release for 12 hours, when compared to marketed tablets. Keywords: Controlled Release Tablets, Diltiazem Hydrochloride, Ethyl Cellulose and Ethyl Vinyl Acetate
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