PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2014, Vol 4, Issue 5
Abstract
Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated for its particle size, drug content and in vitro dissolution studies. The above mentioned method showed similar particle size and exhibited an improvement in the drug entrapment efficiency. The ultraviolet spectrophotometric method was used to analyze Glibenclamide at 300 nm in different buffers. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Glibenclamide.
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- EP ID EP497254
- DOI 10.22270/jddt.v4i5.982
- Views 88
- Downloads 0
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