Preparation and evaluation of pulsatile drug delivery of Metaprolol succinate
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 6
Abstract
In the present study, an effort was made to develop the pulsatile drug delivery of Metaprolol succinate to the colon. A time delayed capsule was prepared by sealing the microspheres inside the insoluble hard gelatin capsule body with erodible hydrogel plug. The microspheres were prepared by emulsion solvent evaporation technique. Optimized microsphere formulations were selected based on dissolution studies. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. Hydrogel plug (HPMCK100 and lactose in 1:1 ratio) having 4.5kg/cm2 hardness and 100 mg weight was placed in the capsule opening and found that it was satisfactory to retard the drug release in small intestinal fluid and to eject out the plug in colonic fluid and releasing the microspheres into colonic fluid after a lag time criterion of 5 hours. In order to simulate the pH changes along the GI tract, three dissolution media with pH 1.2, 7.4 and 6.8 were sequentially used. FTIR study confirmed that there was no interaction between drug and polymer. Among all the formulations Metaprolol succinate microspheres prepared with cellulose acetate in 1:2 ratio shown prolonged release for a period of 12 hours. The obtained results revealed the capability of the system in delaying drug release for a programmable period of time and can prevent a sharp increase in the blood pressure during the early morning hours, a time when the risk of hypertension is the greatest.
Authors and Affiliations
N. Narasimha Rao, Pankaj Sharma V. Saikishore
Keywords
Related Articles
- EP ID EP33347
- DOI -
- Views 288
- Downloads 0
Transfersomes: Novel vesicular carriers for enhanced transdermal drug delivery of Candesartan cilexetil
The aim of this research activity is to formulate Soyalecithin based transfersomal nanoparticles for percutaneous administration of Candesartan cilexetil for better management against cardiovascular diseases. The I.R p...
Soil analysis of Pothavaram village, Prakasam district, Andhra Pradesh, India for the determination of Organic Matter, Sulphur, Zinc and Boron
Soil analysis was conducted in Pothavaram village, Prakasam District, Andhra Pradesh, India, for the determination of Organic matter, Sulphur, Zinc and Boron. Soil analysis is a useful tool for the estimation of micro...
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DESVENLAFAXINE AND CLONAZEPAM IN BULK & TABLET FORMULATION BY RP-HPLC METHOD
The present work is a simple, precise, accurate, efficient and reproducible RP-HPLC method was developed and validated for the simultaneous estimation of Desvenlafaxine and Clonazepam in combined dosage form. Chromatog...
A new method development and validation for the simultaneous estimation of Zolpidium and Melatonin by using RP HPLC in a bulk and pharmaceutical dosage forms
A simple and selective Liquid Chromatography method was described for the determination of Melatonin and Zolpidem tartarate in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile p...
Formulation and in-vitro evaluation of Aceclofenac loaded topical Emulgel
Gels are a relatively newer class of dosage form created by entrapment of large amounts of aqueous or hydro alcoholic liquid in a network of colloidal solid particles. Gel formulations generally provide faster drug rele...