Preparation and Evaluation of Theophyllinepress Coated Tablet
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
:The present research work focuses on the development and evaluation of theophylline press coated tablet, showing controlled release pattern consigned with chronotherapeutics aspects. Provided HPMC K100LV and HPMC K4M were used in the different formulation as coating polymer for development of press coated tablet for controlled release. The formulation powder mixtures were evaluated for pre-compression parameters such as angle of the repose, bulk density, tapped bulk density, Carr’s index and Hausner’s ratio. Batches containing combination of HPMC K100LV and K4M controlled the drug release better at low concentration of high viscosity grade and it was used to optimize the formulation for pulsatile release. The core tablet and final press coated tablets were characterized, in which tablet (F4) gives satisfactory results as it released the drug with predetermined lag time of 6 h but lag time get increases with increase in amount of polymer HPMC K100 LV and HPMC K4M. By using low viscosity grades of HPMC it was possible to obtain a drug plasma peak at 6 to 7 h after administrating to achieve the main aim of the study. From accelerated stability study it was concluded that there was no much effect of the temperature and moisture on the hardness, drug content, and in-vitro drug release from pulsatile press coated tablet.
Authors and Affiliations
Karle P. P. ,, Waghmare B. G, Dhumale A. J. A, Potulwar A. P
Keywords
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