PREPARATION AND EVALUATION OF ULTRASOUND TRANSMISSION GEL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Objective: Formulation of an alternative ultrasound transmission gel that is of good quality using the available chemicals in Iraqi market and without any harmful effects to skin. Methods: Four formulas G1, G2, G3, and G4 with different Carbopol 934 concentrations (0.3, 0.4, 0.5, and 0.6) w/v%, respectively, were prepared and evaluated for different physicochemical characteristics including: Clarity, homogeneity, density, pH, viscosity, and spreadability tests. Other evaluations including skin irritation, microbiological, and stability tests were also performed for the selected formula along with a comparison study with the commercially available ultrasound gel (commercial gel [CG]) which was used as a control. In addition, transmission test was carried out by comparing the transmission between (CG) and (G1) with the assistance of three veterinary radiologists who did ultrasonography of bovine liver for 11 adult cattle breed, aged 3–8 years. The three veterinary radiologists were given 33 data sheets to collect results.Results: Among all the prepared formulas (G1), the formula was considered the best, due to its high clarity, very good homogeneity; its pH was equal to 6.8 which is near to skin pH. Other parameters such as density, viscosity, torque percent, and spreadability showed no significant difference (p≤0.05) with CG. Skin irritation test which was conducted on animals and humans showed no any adverse effects on skin. Microbiological test manifested that using methylparaben alone was sufficient to prevent the growth of microbes in the gel. The three veterinary radiologists found no significant difference (p≤0.05) between G1 and CG formulations. Stability study indicated that the gel was stable after storage at room temperature for 3 months.Conclusion: The overall results suggest that the selected formula (G1) can be considered a successful ultrasound gel and can be used as a good and cheap alternative of the marketed imported gel.
Authors and Affiliations
Amina M Al-nima, Myasar Al-kotaji, Osamah Al-iraqi, Zahraa H Ali
Keywords
Related Articles
- EP ID EP607175
- DOI 10.22159/ajpcr.2019.v12i1.30150
- Views 102
- Downloads 0
EVALUATION OF ANTIMICROBIAL EFFICIENCY AND ΑLPHA-GLUCOSIDASE INHIBITION OF RUBUS ELLIPTICUS SMITH. LEAF EXTRACTS AND ITS PHYTOCHEMICAL ANALYSIS
 Objective: The aim of this study was to investigate phytochemicals, antimicrobial and α-glucosidase inhibition effects of Rubus ellipticus.Methods: Various solvent extracts were investigated for its phytochemical anal...
EFFECTS OF DRUGS IN OPTIMIZING BLOOD PRESSURE AND CARDIAC OUTPUT
In the cardiovascular system the drugs effects the conditions like  Peripheral vascular tone ,Inotropic state of the heart ,Chronotropic state of the heart Clinically these drugs are used in ,Acute ischemic heart diseas...
CRYPTOCOCCOSIS IN ADVANCE STATE OF AIDS AND ITS CHALLENGING THERAPEUTIC REGIMEN: IS IT REALLY CURABLE?
Cryptococcosis followed by Cryptococcal meningitis (CM) is a deadly disease in an immuno-compromised patient with the complication of advancehuman immunodeficiency virus/AIDS, which comes through an air born virus Crypto...
DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF NEBIVOLOL HYDROCHLORIDE AND CILNIDIPINE
Objective: The proposed method describes method development and validation of nebivolol hydrochloride and cilnidipine in combined pharmaceutical tablet dosage form by high-performance thin-layer chromatography (HPTLC) ha...
ANTIOXIDANT ACTIVITIES AND TOTAL PHENOLIC AND FLAVONOID CONTENT VARIATIONS OF LEAF EXTRACTS OF LAURUS NOBILIS L. FROM MOROCCO
Objective: The present study was undertaken to determine antioxidant activity and total phenolic and flavonoid content of ethanol, methanol, ethyl acetate, and aqueous extracts of the leaves of Laurus nobilis L.Methods:...