Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacin
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2018, Vol 10, Issue 1
Abstract
The implantable drug products are developed mainly to sustain the drug release. This study was conducted to formulate and evaluate cross-linked films of chitosan/β-glycerophosphate (β-GP) for the sustained delivery of enrofloxacin (ENR). Two types of formulations, single-layer (F1 and F2) and triple-layer (F3 and F4) films, were prepared. In vitro drug release, kinetic modelling, Fourier transform infrared spectroscopy (FTIR) spectra, morphological and microbiological studies were performed. Drug release from F1 and F2 continued up to 5 hours but from F3 and F4, it was extended over 96 and 168 hours, respectively. The cumulative drug release for F1, F2, F3 and F4 were 72.6, 70.1, 90.5 and 82.4%, respectively. The inhibition zones of bacterial growth by using positive controls and single layer films were significantly greater than those of triple-layer films (p < 0.05), indicating sustained drug release pattern of the multi-layer films. These findings suggest that the triple-layer chitosan/β-GP films could be effective to deliver ENR for a long period.
Authors and Affiliations
Ali Rassouli,Sakineh Khanamani Falahatipour,Yalda Hosseinzadeh Ardakani,Hamid Akbari Javar,Katayoun Kiani,Taghi Zahraee Salehi,
Keywords
Related Articles
- EP ID EP722408
- DOI -
- Views 49
- Downloads 1
Therapeutic Effects of ADU-S100 as STING Agonist and CpG ODN1826 as TLR9 Agonist in CT-26 Model of Colon Carcinoma
Cancer immunotherapy emerged as a novel therapeutic approach to destroy tumor cells, and it has grown toward clinical transition following successful fundamental research and clinical trials. Immunotherapy by efficacious...
Helicobacter Detection in the Stomach of Apparently Normal Donkeys: Sampling, Diagnostic Methods, and Implications for Equine Glandular Gastric Disease and Serum Antioxidant Status
The involvement of Helicobacter-like agents in EGGD is not clear. Much evidence supports the presence of Helicobacter in the horse’s stomach, but it is not so clear about the donkey. The present study was conducted to ev...
Clinical evaluation of tarsocrural luxation with malleolus fracture surgical treatment in dogs: A case series
The aim of this study was to evaluate the long-term outcome of treatment using Kirschner wires and tensioning bands for tarsocrural luxation with malleolus fractures resulting from trauma in dogs. Eight dogs with tarsocr...
The effect of Artemisinin on the Pentylentetrazole-induced seizures during the estrous cycle and GABA interaction in mice
Catamenial epilepsy may involve 10 to 70% of women with epilepsy in which, seizures are exacerbated by the menstrual cycle. Artemisinin is a herbal compound with widespread modern and traditional medical indications. Bec...
Histopathological changes in experimental infestation of Paederus fuscipes in rats
The genus Paederus consists of approximately 621 species associated with outbreaks of dermatitis. Our aim was to determine gross and microscopic changes induced by Paederus fuscipes. Adult P. fuscipes beetles were collec...