Preparation and in-vitro Evaluation of Ranitidine Mucoadhesive Microspheres for Prolonged Gastric Retention
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 10, Issue 2
Abstract
Aim: The purpose of this study was to prepare and characterize mucoadhesive microspheres of Ranitidine (RNT) for prolonged gastric retention. Materials and Methods: Mucoadhesive microspheres were prepared by ionic gelation method using the polymer Sodium alginate (SA) along with various copolymers like Sodium Carboxy Methyl Cellulose (SCMC), Hydroxy Propyl Methyl Cellulose K100 (HPMC K100), Carbopol 934P (Car 934P), Eudargit RS100 (Eud RS100) and characterized by the parameters like particle size, micromeritic properties, drug entrapment efficiency, swelling index, mucoadhesion capacity and in-vitro drug release. Results: FTIR studies confirmed that there was no chemical interaction between the drug and polymers. The flow properties were found to be excellent and in-vitro drug release study was performed in pH 1.2 HCl buffer for 24 h time duration. From the in-vitro release studies, formulations F1, F5 and F8 showed optimum drug release, thereby optimized for further study. Conclusion: Kinetic studies proved that the drug release from the microspheres followed zero order kinetics and mechanism was found to be diffusion, particularly non-fickian or anomalous transport. Relatively formulation F1 showed better results than the F5 & F8 formulations.
Authors and Affiliations
K. Vijayabhaskar, Kambham Venkateswarlu, S. B. Thirumalesh Naik, R. Kiran Jyothi, G. Nethra Vani, K. B. Chandrasekhar
Keywords
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- EP ID EP342399
- DOI 10.9734/BJPR/2016/22670
- Views 101
- Downloads 0
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