A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 1
Abstract
Novel, less toxic, more effective catalysts were used to synthesize various flavones under auto clave conditions. Substituted o- hydroxyl acetophenones and benzaldehydes were reacted in-presence of 2, 4, 6-trimethylpyridine, a pinch of TiCl4 and yielded chalcones. Equimolar ratio of KIO3, KI, and H2SO4 was used as in situ catalytic source for I2 to convert chalcones to flavones. The progress of the reactions was monitored by TLC. Crude compounds were recrystallized from methyl alcohol. We obtained good yields of products within less time periods. We had gone through IR, HNMR, Elemental analysis and mass data to characterize the compounds. Selective compounds were screened for cytotoxic activity against A549 human tumour cell lines by MTT method and comparative study has been done.
Authors and Affiliations
K. Rajeshbabu, S. Pushpalatha, B. Ramakrishna, V. Madhavarao
Keywords
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- EP ID EP342063
- DOI 10.9734/BJPR/2016/15884
- Views 63
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