Preparation and Study of Stability Pharmaceutical Composition [PSMA-11] and Radiopharmaceutical [99mtc]-PSMA-11 Labeled With 99mtc Radionuclide
Journal Title: International Journal of Advanced Research in Science and Technology (IJARST) - Year 2024, Vol 13, Issue 2
Abstract
This work is devoted to the study of the synthesis of a pharmaceutical composition (PhC) [PSMA-11] in the form of a lyophilisate with optimization of the amount of ingredients and sodium pertechnetate (Na99mTcO4) from the 99mTc Generator to obtain the radiopharmaceutical [99mTc]-PSMA-11 with the highest possible radiochemical yield (RCY) and radiochemical purity (RCP). The stability of radiopharmaceutical [99mТс]-PSMA-11 in 0.9% NaCl solution and in human serum was determined. The preliminary shelf life of PhC [PSMA-11] was determined and set to 6 months.
Authors and Affiliations
*Usarov Z. O1 . , Khujaev S2 . , Abdukayumov A. M1 . , Rikhsiev A. Z1 . , Hajiev L. O1 .
Keywords
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- EP ID EP737944
- DOI 10.62226/ijarst20241318
- Views 56
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Preparation and Study of Stability Pharmaceutical Composition [PSMA-11] and Radiopharmaceutical [99mtc]-PSMA-11 Labeled With 99mtc Radionuclide
This work is devoted to the study of the synthesis of a pharmaceutical composition (PhC) [PSMA-11] in the form of a lyophilisate with optimization of the amount of ingredients and sodium pertechnetate (Na99mTcO4) from th...