Preparation, biodistribution and scintigraphic evaluation of 99mTc-lincomycin
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
A complex of lincomycin was synthesized with technetium-99m. The synthesis was carried out by using SnCl2.2H2O as reducing agent and ascorbic acid as stabilizer. The effect of various parameters such as amount of ligand/reducing agent, pH value and reaction time on radio labeling process was studied. The characterization of the 99mTc-Lincomycin was performed by HPLC and electrophoresis Biodistribution studies were carried out by analyzing the model of bacterial infectious rats (Sprague-Dawley). The uptake of infectious lesions at different time interval was also studied by using scintigraphic technique. The complex showed effective target to non-target ratio for various inflammatory or infectious lesions. The 99mTc-Lincomycin effective binding to living bacteria and could be used successfully as an infection imaging agent.
Authors and Affiliations
Tanveer Hussain Bokhari , Faheem Askari Rizvi , Samina Roohi , Saira Hina , Mushtaq Ahmad , Muhammad Khalid , Munawar Iqbal
Keywords
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