Pre/post-surgical investigation of some angiogenic factors due to cancer and obesity

Journal Title: Medical Science and Discovery - Year 2018, Vol 5, Issue 1

Abstract

Objective:   Obesity is one of the important health problem for developed and developing countries. Due to literature some obesity related factors may trigger the tumor formation. For tumor development, tumoregenic cell and tissue  needs to oxygen and nutrients. Once the tumor has developed, it stimulates the angiogenesis by producing chemical signals and grows by supplied oxygen and nutrients with newly formed vessels. Aim of this study is to compare some angiogenic factors before and after surgery which will supply more information about the link between the cancer and obesity. Material and Methods: Serum samples were obtained before and 48 hours after surgery. Adrenomedullin, vascular endothelial growth factor, hipoxia inducible factor1-α and matrix metallo proteinase-2 levels were investigated in cancerous and noncancer patients. Angiogenic factors were assayed by ELISA method. Results: Higher levels of angiogenic factor were detected in cancer tissues more than in non-cancer tissues, in pre-obese and obese patients. It is seen that in humans, in post-operated patients angiogenic factors are higher in obese individuals, while non-cancer patients are also higher in obese groups and angiogenic factors which stimulate angiogenesis. Conclusion: In the treatment of cancer, as defined previously the anti-angiogenic factors should be considered and applied as epigenetic phenomen. Due to our finding cancer related elevated angiogenic and growth factor biochemicals had been also increased in obes population and in cancer patients with surgical intervention. In the light of literature and our findings, instead of drugs, radiation therapy or surgery, which have many side effects in the treatment of cancer, we need to focus to this epigenetic phenomen for cancer patients. In general, we can say that both obesity and surgical applications lead to an increase in angiogenic factor levels, and that the healing process of wounds causes a marked increase in angiogenic factor levels

Authors and Affiliations

Sertac Ata Guler, Atilla Yurekli, Nuh Zafer Canturk, Gokhan Posteki, Turgay Simsek, Ozan Can Tatar, Muhittin Yurekli

Keywords

Related Articles

Familial Recurrent Hydatidiform Moles: A rare case report

Recurrent hydatidiform moles (RHM) are described as the being of at least two molar pregnancies in the same patient. It is very rare. NLPR7 mutations are found high rate in patients with RHM. KHDC3L is the second respons...

Complete heart block and acute inferior myocardial infarction due to generalized vasospasm

Sixtyone years old female patient had applied to emergency department with chest pain. Her ECG taken was compliant with acute inferior myocardial infarction and complete heart block. In her coronary angiography (CAG), th...

An unusual cause of delayed full enteral feeding and prolonged hospital stay in a newborn with gastroschisis: Congenital Hypothyroidism

Gastroschisis, is a prevalently encountered congenital disease of the newborns where intraabdominal organs protrude through a full-thickness defect in the anterior abdominal wall without an overlying sac. In recent years...

A case report of human infestation with pubic louse (Pthirus pubis) in Sarab city, Iran

Lice were collected from 47 years old male worker on his complaint for itching and red rashes on body. The lice thus collected were subjected to microscopic examinations and identified as Phthirus pubis, commonly known a...

Extrude-Sequestrum Spontaneous Regression of Lumbar Disc Hernia: Case Report

The correct approach to the lumbar disc hernia is subject to debate. Although a rare case of lumbar disc herniation with spontaneous regression, to be seen and is a well-known phenomenon commonly reported. But the underl...

Download PDF file
  • EP ID EP520723
  • DOI 10.17546/msd.373798
  • Views 43
  • Downloads 0

How To Cite

Sertac Ata Guler, Atilla Yurekli, Nuh Zafer Canturk, Gokhan Posteki, Turgay Simsek, Ozan Can Tatar, Muhittin Yurekli (2018). Pre/post-surgical investigation of some angiogenic factors due to cancer and obesity. Medical Science and Discovery, 5(1), 97-102. https://europub.co.uk/articles/-A-520723