Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 3
Abstract
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be life-threatening. Objectives: The study was conducted to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal(GI) risk factors of orthopedic adult inpatient.Materials and methods: A prospective observational NSAIDs induced GI risk related study was conducted over a period of 6 months by clinical pharmacist. Study cohort included 105 orthopaedic inpatients who are taking or will be taking NSAIDs for more than a week. A self-administered questionnaire was completed by each patient. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients‟ risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings.Results: The study groups were stratified into four risk groups according to GI SCORE tool, 27.6% of the patients belonged to high risk or very high risk groups for GI complications. Analysis of prescription pattern revealed that 11.4% of the patients aged over 65 yr, 19% with co morbid disease were prescribed with COX-2 selective inhibitor. Conclusion: In this study assessment of prescription pattern and GI risk factors for NSAIDs were evaluated and in conclusion, physician‟s considerate prescription of NSAIDs with well-understanding of each patient‟s GI risk factors is strongly encouraged to prevent serious GI complications
Authors and Affiliations
Anita P Antappan| Pharm D Interns, Department of pharmacy practice , St,James college of Pharmaceutical Sciences, KUHS University, Chalakudy, Kerala, India, Bibin Punnoose Micheal| Pharm D Interns, Department of pharmacy practice , St,James college of Pharmaceutical Sciences, KUHS University, Chalakudy, Kerala, India, Merin Anto Thelappilly| Pharm D Interns, Department of pharmacy practice , St,James college of Pharmaceutical Sciences, KUHS University, Chalakudy, Kerala, India, Thazneem Bagum T. D| Pharm D Interns, Department of pharmacy practice , St,James college of Pharmaceutical Sciences, KUHS University, Chalakudy, Kerala, India, Leo Mathew| Assistant Professor, Department of Pharmacy Practice, St,James college of Pharmaceutical Sciences, KUHS University, Chalakudy, Kerala, India, L. Panayappan| Head of the Department, Department of Pharmacy Practice, St,James college of Pharmaceutical Sciences, KUHS university, Chalakudy, Kerala, India, K . Krishnakumar| Principal, St, James college of Pharmaceutical Sciences, KUHS University, chalakudy-680307, Kerala, India
Keywords
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