Presence of Circulating Lactate DehydrogenaseImmunoglobulin G (LDH-IgG) Complex in the Sera of PostBurn Patient
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 3
Abstract
Lactate dehydrogenase (LDH) is an enzyme that belongs to the class oxidoreductase. It actively participates in the inter-conversion of lactate to pyruvate during anaerobic glycolysis in cell cytoplasm. Available literature suggests that there exist only five isoenzymes of LDH which on polyacrylamide gels (Native PAGE) resolve into five bands in normal healthy individuals. However, the presence of extra band in humans is either detected in reproductive tissues or during some pathological state. Here, we report a case in which an extra sixth band of LDH was visualized which forms a complex with IgG in the circulating sera of burn subject. The presence of LDH-IgG complex was confirmed in freshly collected sera using PAGE and immunological approaches. The complex get disappears from 2nd day onwards. The probable reason of the formation of this complex and its relation with the progression of the disease is discussed.
Authors and Affiliations
Riaz Ahmad| Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh-202 002 (U.P), India, Absar-ul Hasnain| Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh-202 002 (U.P), India, Arshad Hafeez Khan| Department of Plastic & Reconstructive Surgery, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh-202 002 (U.P), India, Mumtaz Alam| Department of Plastic & Reconstructive Surgery, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh-202 002 (U.P), India
Keywords
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- EP ID EP8765
- DOI 10.3889/MJMS.1857-5773.2010.0140
- Views 368
- Downloads 21
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