Prevalanace of MDR-Tuberculosis in A Tertiary Care Hospital in Haryana
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Drug resistant TB is on rise in world and India, and the most common risk factor for MDR TB is previous treatment history that is failure, relapse, default cases. This study was undertaken in our hospital to determine prevalence of MDR TB in retreatment cases. Material and Methods: This prospective observational study was conducted in MMIMSR Haryana, which included 100 Category II pulmonary TB patients who satisfied the inclusion criteria. Sputum samples of these patients were tested for drug resistance using L.P.A. Results were analyzed and the prevalence of MDR calculated. Then MDR patients were compared with the Non MDR ones with reference to age, gender, habits, previous treatment history, clinical features, and drug susceptibility pattern. Results: The prevalence of MDR in Cat II patients was found to be 20%, statistically significant association was seen between following failure cases and MDR TB, alcohol abuse and MDR TB, alcohol+smoking and MDR TB, Diabetes mellitus and MDR TB. Only a single case of Isoniazid mono resistance was found, no case of Rifampicin mono resistance was found. Conclusion: The prevalence of MDR is high and fast increasing in retreatment cases and since these patients are at higher risk of morbidity, mortality and risk for infecting others with MDR strains, immediate measures for early diagnosis and proper treatment should be instituted and the patients should be counseled appropriately regarding compliance to treatment. We also stress on need of more studies which would establish risk factors of MDR TB in India.
Authors and Affiliations
Mohammad Zaeem Khan, Sammer Singhal, Atulya Atreja, Dinesh Mehta, Sachin Bansal, Abinav Dagar
Keywords
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