Prevalence and causality assessment of adverse drug reactions; clinical consequences of drug interactions and polypharmacy in patients presenting to a secondary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 2
Abstract
Background Drug use is frequently considered to be hazardous for an elderly, due to greater vulnerability of an elderly to drugs and multiple drug use. Poly-pharmacy is unavoidable in the elderly as they suffer from multiple co-morbidities. Adverse drug reaction (ADR) is the sixth leading cause of death. Drug-drug interaction due to polypharmacy and potentially inappropriate medication must be carefully assessed. Material and methods The study was conducted in both Inpatient and Outpatient in all departments of Thumbay Hospital New Life, Hyderabad for 6 months from October 2018 to March 2019.537 prescriptions was randomly collected and evaluated for adverse drug reactions and clinical consequences of drug interactions and polypharmacy in patients presenting to a secondary care Hospital. Results A total of 537 patients were observed of which 203 patients experienced ADR’s which accounted for 21.5% of the incidence and 143 DDI’s were observed. Most of the DDI’s were Pharmacokinetic drug interactions (26.7%) followed by Pharmacodynamic drug interactions (12.70%). A severity assessment showed that the majority of DDI’s were moderate 34.96% followed by minor 32.86%. Poly-pharmacy was more frequent in the elderly of age 56-65 (both males and females) and totally 321 ADEs were observed and the incidence of ADR’s and DDI’s increased non-significantly as the number of drugs used for long term period. Majority of ADRs were suspected due to antibiotics, anti-hypertensive responsible for causing GI complaints and rash. Neurological system (26%) was the most common organ system affected due to ADRs. In the cases of treating LRTI and urinary tract infections, there was an enormous risk of ADR’s. The number of drugs increases as the age and the co-morbid conditions increases with an average of 20. Conclusion From the present study we can conclude that relatively high incidence of Adverse drug reactions has been recorded which shows that not only geriatric patients but also adults are also more susceptible to ADR’s and poly-pharmacy leads to serious DDI’s and hence to improve drug safety- appropriate prescribing, TDM is important.
Authors and Affiliations
Nagireddy Nagireddy
Keywords
Related Articles
- EP ID EP648132
- DOI -
- Views 63
- Downloads 0
Pharmacovigilance - knowledge, attitude and practice among medical students in a teaching hospital of southern India
Background Drugs although used in the prevention and curing of diseases, are sometimes associated with undesirable adverse drug reactions (ADR). Spontaneous reporting of ADRs has remained the cornerstone and major sourc...
Evaluation of anti-Parkinson's effect of Peganum harmala on haloperidol induced catalepsy in experimental animal model.
Aim of the study To evaluate the neuroprotective activity of ethanolic extract of seeds of Peganum harmala (PHEE) in wistar rat. Materials and methods Ethanolic extract of seeds of Peganum harmala was screened for anti-P...
Cervical lymph Node Enlargement
Cervical lymph nodes are enlarged in almost all neck and head pathologies. Tuberculosis was the major cause for cervical lymphadenopathy. Pathological examination was also mandatory. Lymph node enlargement is seen in a...
To Study the Pharmacological Effect and Beneficial Effect of Eucalyptus Globulus in Different types of Diseases
The plant Eucalyptus globulus, On the basis of study conducted on, it was found that Eucalyptus has storage of active constituent present in its parts; traditionally it is necessary to explore its importance as an excell...
ANTIUROLITHIATIC ACTIVITY OF ACTIVITY OF TECOMA STANS LEAF EXTRACT
Herbal medicines offer vast scope for the successful treatment of urolithiasis. Although most remedies were herbal and proved useful, a systematic scientific evaluation has been reported for only few remedies. Tecoma st...