Evaluation of anti-Parkinson's effect of Peganum harmala on haloperidol induced catalepsy in experimental animal model.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 3
Abstract
Aim of the study To evaluate the neuroprotective activity of ethanolic extract of seeds of Peganum harmala (PHEE) in wistar rat. Materials and methods Ethanolic extract of seeds of Peganum harmala was screened for anti-Parkinson's effect by using behavioral method, haloperidol induced catalepsy at a dose of 50 mg/kg and 100 mg/kg. Distilled water and L-dopa were employed as control and standard groups respectively. Results Peganum harmala at a dose of 100 mg/kg showed maximal decrease in catalepsy (71±4.0 at 60 Minute) as compared to both negative and positive control groups. Conclusion Ethanolic extract of seeds of Peganum harmala may be useful in Parkinson's disease.
Authors and Affiliations
Abdulrahman M
Keywords
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