Prevalence and High-risk groups of NAFLD (Non-Alcoholic Fatty Liver Disease) in Gujarat
Journal Title: Gujarat Medical Journal - Year 2017, Vol 72, Issue 1
Abstract
AIM: METHODS : To get a prevalence of NAFLD in Gujarat and to identify high risk groups. This is a cross-sectional data analysis of various health check-up plans of 422 individuals enrolled consequently for 1 yr. First, Proportions of NAFLD and suspected NASH (Nonalcoholic Steatohepatitis) in the various groups according to Age, Gender, Obesity etc were tabulated to understand distributions. Means of variables (BMI, W/H ratio etc.) among NAFLDs were obtained. Bivariate and multivariate Statistical analysis was between NAFLD with high-risk groups. Secondly, our prevalence was compared to world data to understand NAFLD in this region. Out of 422 subjects, 36.01% (n=152) had NAFLD.Among these, 23.02% (n=35) were suspected NASH. Among males, 44.5 % (n = 107) had NAFLD. This prevalence among dual-obese (morbid and central obese) is 68.7% (n =22, P < 0.001). Multivariate logistic regression model showed BMI (p < 0.001), gender (p < 0.001) and W/H ratio (p < 0.05) have greater influence. Suspected NASH in NAFLD Females is 35.5% (n = 16), which is 17.7% (n = 19) among NAFLD males. Mean BMI and W/H (waist to hip) ratio of NAFLD male were 29.24 ± 4.2 kg/m² and 0.94 ± 0.05 respectively. Among NAFLD females, these were 33.41 ± 6.08 kg/m² and 0.86 ± 0.06. RESULTS: NAFLD prevalence is similar to other parts of world.But, it is lower among obese. Males have higher NAFLD, while females have higher suspected NASH. Dual obese have highest prevalence with higher chance of NAFLD. Nevertheless, BMI is more associated with NAFLD than truncal obesity and than other components of metabolic syndrome. There is significant drop in prevalence, if BMI reduces. We can use cut-offs of BMI, W/H ratio of this study as preventive measure. CONCLUSIONS: NAFLD prevalence is similar to other parts of world.But, it is lower among obese. Males have higher NAFLD, while females have higher suspected NASH. Dual obese have highest prevalence with higher chance of NAFLD. Nevertheless, BMI is more associated with NAFLD than truncal obesity and than other components of metabolic syndrome. There is significant drop in prevalence, if BMI reduces. We can use cut-offs of BMI, W/H ratio of this study as preventive measure.
Authors and Affiliations
Sudhanshu Patwari, Nikhil Lala, Bhavesh Panchal
Keywords
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