PREVALENCE OF AUTOIMMUNE THYROID DISEASE AND THYROID DYSFUNCTION IN TYPE 1 DIABETES MELLITUS PATIENTS- A TERTIARY CARE CENTRE BASED STUDY IN ASSAM MEDICAL COLLEGE AND HOSPITAL, DIBRUGARH, ASSAM
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 86
Abstract
BACKGROUND Patients with an autoimmune condition are known to be at higher risk of developing other autoimmune disorders. Type 1 diabetes mellitus may be associated with additional autoimmune disorders including autoimmune thyroid disease. Studies investigating the autoimmune thyroid disease in T1DM are few. The aim of this study was to investigate the prevalence of anti-TPO antibody and their clinical significance for development of thyroid disorder in patients with T1DM, attending the outpatient and in-patient department of Assam Medical College & Hospital, Dibrugarh. MATERIALS AND METHODS This study was a hospital-based observational study, analysing all the previous and newly diagnosed T1DM patients done from a period of 1st July 2016 to 30th June 2017. 92 T1DM patients were evaluated with anti-TPO antibody by ELISA method and serum TSH measurement was done. RESULTS The anti-TPO antibody positivity was found in 9 out of the 92 patients with overall prevalence of 9.78%. Among the anti-TPOpositive subjects, female to male ratio is 2:1. All the anti-TPO antibody positive patients had abnormal TSH levels and 44.45% had clinically significant hypothyroidism, 22.22% had subclinical hypothyroidism while hyperthyroidism was present in 33.33%. CONCLUSION Our study reveals that there is a moderate prevalence of autoimmune thyroiditis in T1DM patients in this region and they should be followed up with regular screening of anti-TPO and TSH to make an early diagnosis of thyroid dysfunction.
Authors and Affiliations
Pranjal Kumar Dutta, Anupam Dutta, Apurba Dutta, Sanjeeb Kakati, Lahari Saikia5
Keywords
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