Prevalence of Central Nervous System Cryptococcosis In A Tertiary Care Hospital.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Cryptococcosis is a systemic opportunistic fungal infection caused by Cryptococcus neoformans. Cryptococcus neoformans is a capsulated opportunistic yeast fungi that predominantly affects HIV infected and other immonocompromised hosts involving the CNS either as meningitis or meningo encephalitis. Central nervous system Cryptococcus is an important cause of mortality among immuno compromised patients. A prospective study was conducted on a total no. of 150 patients who were suffering from CNS symptoms with cryptococcal meningitis and other co-morbid conditions like diabetes, corticosteroid use, chronic debilitating illness and in HIV/AIDS patients. The aim of the study was detection and isolation of cryptococcus neoformans in CSF samples of immunocompromised other co-morbid conditions like diabetes, corticosteroid use and chronic debilitating illness patients who suffered from suspected cryptococcal meningitis at Govt. General Hospital, Guntur. This study helps to assess the prevalence of CNS Cryptococcosis in immunocompromised individuals including HIV/AIDS patients. This helps the clinician and community to take proper measures & proper patient care. 150 CSF samples are screened by various cryptococcal investigations (India ink / gramstaining / culture / CALAS). Prospective study was conducted from July 2015 to December, 2015 for a period of 6 months. Of the total 150 cases, males were more commonly involved than females with the ratio 2:1. The total prevalences of Cryptococcus was 16% in high risk patients, where in HIV positive prevalence is 12.6% in diabetes mellitus 2.6% and others it is 0. 8%. Routine mycological evaluation is necessary for early definite diagnosis and proper treatment. This will decrease morbidity and mortality.
Authors and Affiliations
Dr. D. Lavanya, Dr. B. Venkata Rao, Dr. P. Kamala, Dr. K. Ravi Kiran
Keywords
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- EP ID EP237978
- DOI 10.9790/0853-1611015760
- Views 133
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