PREVALENCE OF CLOSTRIDIUM DIFFICILE TOXIN IN DIARRHOEAL STOOL SAMPLES OF PATIENTS FROM A GENERAL HOSPITAL IN EASTERN PROVINCE, SAUDI ARABIA
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 2
Abstract
Introduction: Clostridium difficile is anaerobic spore- forming bacillus, produces two major toxins (Tcd A and Tcd B). Disease caused by toxigenic C.difficile (Tcd) varies from mild diarrhea to fulminant disease and death. Aims and Objectives: - This study describes the prevalence of C.difficile toxins (CDT) in stool samples from in patients and outpatients of all age groups. Materials and Methods:- A total of 146 samples were examined from 2011 to 2012 were analyzed for the presence of CDT tests, DNA amplification test, and the stool samples were cultured anaerobically on CCFA selective medium for growth- Morphology, identification and other tests. The patient’s details are collected from the medical records. Results: - Out of 146 specimens, only 20 (13.7%) were positive for C.difficile toxins. Male and female were 12 (60%) and 8(40%) respectively, with the majority of them aged between 16 to 71 years. Majority of them were from out patient units (n = 5, 25%) with rest from intensive care units (n = 3, 15%), male medical ward (n =3, 15%) and surgical wards (n = 1, 5%). All the CDT positive patients had history of prior antibiotic usage before the detection of toxin. Mean duration of antibiotic usage was a 16.75 (±12.75) days, and the mean duration of diarrhea was 4.21 (±4.85) days, 16 patients had underlying medical illness, like hypertension, diabetic mellitus etc; Stool with pus cells and occult blood test was positive among that 18 patients were positive for CDT. The hospitalized patient duration was 20.96 (±16.25) days. Conclusion: - The detection of CDT in the diagnosis of CDI requires vigilance by both clinician and microbiologist to look out for possible infected patients. Antibiotic usage is a known risk factor; thus restricted use of antibiotics may results the reduction of CDI.
Authors and Affiliations
Sue Elizabeth Shajan| PhD Scholar, Dept of Microbiology, School of life Sciences, Karpagam University, Coimbatore, Tamil Nadu, India & Currently affiliated to Department of Microbiology, Al Mana General Hospital, Al Jubail, Saudi Arabia, Corresponding author email: sueshajan@gmail.com, sueshajan@yahoo.com, Mohammed Faisal Hashim| Department of Medicine, Al Mana General Hospital, Al Jubail, Saudi Arabia, Michael A| Department of Microbiology, PSG College of Arts& Science, Coimbatore, Tamil Nadu, India
Keywords
Related Articles
- EP ID EP11163
- DOI 10.5958/j.2319-5886.3.2.064
- Views 287
- Downloads 15
UNMET NEED OF SEX EDUCATION AMONG ADOLESCENTS IN URBAN SLUM AREA: AN INTERVENTIONAL STUDY
Context: Adolescents comprise one-fifth of India’s total population. There is widespread ignorance associated with unprotected sex, contraceptives, among young people. As majority adolescents in slum areas have illite...
STUDY AMONG BETEL QUID CHEWERS FROM INDIAN POPULATION
Background: Oral cancer is most common in males and also in females. Betel quid (BQ) is the main causative agent of oral cancer. Areca catechu, a major component of BQ, contains certain alkaloids that give rise to nitr...
Investigating the effect of home care program on self-efficacy of femaleheaded single-parent households supported by Isfahan Welfare Organization (Behzisti) in year 1394
Introduction: Female-headed households are among the most vulnerable groups of society and there are potential of many critical jeopardies for these families. Therefore, this study was focused to evaluate the effect of...
Speciation and antibiotic resistance pattern of Acinetobacter species in a tertiary care hospital in Uttarakhand
Acinetobacter species are Gram negative nonfermentative bacteria that have now emerged as important nosocomial pathogens involved in outbreaks of hospital infections.They are considered as opportunistic pathogens that r...
BENIGN OCCIPITAL EPILEPSY OF CHILDHOOD: PANAYIOTOPOULOS SYNDROME IN A 3 YEAR OLD CHILD
Panayiotopoulos syndrome (PS) is a relatively frequent and benign epileptic syndrome seen in children in the age group of 3-6 years and is characterised by predominantly autonomic symptoms and/or simple motor focal seiz...