PREVALENCE OF FAILURE OF FIRST-LINE ANTIRETROVIRAL THERAPY- STUDY AT RIMS, A TERTIARY CARE HOSPITAL AT ONGOLE, PRAKASAM DISTRICT OF ANDHRA PRADESH
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 22
Abstract
BACKGROUND HIV infection is not the end of life. Anti-retroviral therapy (ART) effectively suppresses replication. But adherence to ART regimen is therefore very vital. Any irregularity in following the prescribed regimen can lead to resistance to HIV drugs and therefore can weaken or negate its effect. MATERIALS AND METHODS A retrospective descriptive study was done from the ART centre at Rajiv Gandhi Institute of Medical Sciences (RIMS), Ongole. Data from case sheets was collected in a pre-designed format. This study was conducted from 2007 to 2017. Treatment failure is identified by clinical and/ or immunological and confirmed by the virological criteria. RESULTS Among the total of 8119 patients, total first-line failures who were on second-line drugs were 254; hence, the prevalence of failure of first-line anti-retroviral therapy being 3.12%. Out of the total first-line failures, 133 (52.4%) were males and 121 (47.6%) were females. The mean age of the first-line failures was 37.52 ± 10.41 years. Mean baseline CD4 count was 195.42 ± 81.56 mm3. CONCLUSION The overall prevalence of first-line anti-retroviral therapy was found to be 3.12% with a slight male preponderance and majority belonged to relatively younger age group. Constant monitoring and individual counselling on all aspects of the treatment would play an important role.
Authors and Affiliations
Gudi Srinivas, Yarram Rajeswara Rao, Jyothula Joseph Samuel
Keywords
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- EP ID EP433349
- DOI 10.14260/jemds/2018/606
- Views 94
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