Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal
Journal Title: Journal of Advances in Internal Medicine - Year 2013, Vol 2, Issue 4
Abstract
Background and aims: The Helicobacter pylori (H. pylori) prevalence in Asian countries is highly variable, with higher seroprevalence shown in the previous studies of developing Asian countries. We aimed to determine the current H. pylori prevalence, correlate with gastroduodenal diseases and study gastric cancer incidence in Nepal. Methods: Among 3357 patients referred for endoscopy, 2820 eligible patients underwent upper gastrointestinal endoscopy with biopsy; H. pylori was considered positive when either of Rapid Urease Test (RUT) or histopathology showed positive result. Results: The H. pylori prevalence was 29.4% in overall distribution, 41.1% in gastritis and or duodenitis, 69.5% in gastric ulcer, 84.7% in duodenal ulcer, 20.8% in gastric polyp and 11.5% in gastric cancer. The H. pylori infection was significantly associated with gastritis and or duodenitis [P<0.001; Odds Ratio (OR) 1.53, 95% Confidence Interval (CI) 1.47-1.59], gastric ulcer (P<0.001; OR 18.62, 95% CI 12.40-27.81), duodenal ulcer (P<0.001; OR 48.89, 95% CI 25.23- 94.75), gastric polyp (P=0.001; OR 7.66, 95% CI 3.18-18.44) and gastric cancer (P=0.005; OR 3.78, 95% CI 1.82-7.86). The age-standardized (world) annual rate of gastric cancer in Kaski district of Nepal was 3.3 per 100,000. Conclusions: The H. pylori prevalence in Nepal was lower than that shown in the previous studies of developing Asian countries, but was significantly high in gastritis and or duodenitis, and peptic ulcers. Similarly, the gastric cancer incidence was also low in Nepal and was significantly associated with H. pylori. Further study is needed to establish the association of H. pylori with gastric cancer in Nepal.
Authors and Affiliations
Umid Kumar Shrestha*| Deparment of Medicine, Manipal College of Medical Sciences and Manipal Teaching Hospital, Pokhara, Nepal,Deparment of Medicine, Kaski Sewa Hospital and Research Center, Pokhara, Nepal, Arnab Ghosh| Department of Pathology, Manipal College of Medical Sciences and Manipal Teaching Hospital, Pokhara, Nepal, Vijay M Alurkar| Deparment of Medicine, Manipal College of Medical Sciences and Manipal Teaching Hospital, Pokhara, Nepal, Suresh C Kohli| Deparment of Medicine, Manipal College of Medical Sciences and Manipal Teaching Hospital, Pokhara, Nepal, Subash Sapkota| Deparment of Medicine, Manipal College of Medical Sciences and Manipal Teaching Hospital, Pokhara, Nepal,Deparment of Medicine, Kaski Sewa Hospital and Research Center, Pokhara, Nepal
Keywords
Related Articles
- EP ID EP4769
- DOI http://dx.doi.org/10.3126/jaim.v2i2.8777
- Views 439
- Downloads 22
Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal
Background and aims: The Helicobacter pylori (H. pylori) prevalence in Asian countries is highly variable, with higher seroprevalence shown in the previous studies of developing Asian countries. We aimed to determine the...
Trends and in- hospital mortality of Acute Coronary Syndrome at Shahid Gangalal National Heart Centre, Kathmandu, Nepal during 2001-2012
Background and aims: Acute coronary syndrome (ACS), which comprises acute ST-segment elevation myocardial infarction, non-ST segment elevation myocardial infarction and unstable angina is a major health problem and repre...
White Coat Hypertension, relationship of stages of hypertension with end organ damage and diurnal variation of blood pressure in newly diagnosed hypertensive patients
Introduction - Systemic hypertension is a disease attributable for various cardiovascular events. White coat hypertension is under diagnosed in Nepal and is usually treated as hypertension. However its prevalence in Nepa...
AN EVALUATION CONTROL OF COTTON BOLLWORM HELICOVERPA ARMIGERA (HUB.) IN THE NORTHERN IRAN
Helicoverpa armigera (Hub.) is the major pest of cotton in Golestan province. The present study was carried out during 2002-2003 in Fazel-Abad region of Iran in RCBD design with 6 treatments and 4 replications to compare...
Rituximab Monotherapy for Primary Cutaneous Follicle Center Lymphoma
Primary cutaneous follicle center lymphoma is a rare disorder. Although there are several treatment options, large clinical trials on the treatment of primary cutaneous follicle center lymphoma are lacking. Optimal treat...