Prevalence of hypothyroidism and its association with anti-thyroid peroxidase antibody among adult sea food consuming population attending a tertiary health care centre in Kerala
Journal Title: International Journal of Biomedical and Advance Research - Year 2015, Vol 6, Issue 9
Abstract
Background: Thereis less data on the prevalence of hypothyroidism in adult population of India. Currently with iodine supplementation and availability of iodine rich nutritious food,the iodine deficiency etiology in hypothyroidism is no more applicable. So it is useful to estimate thyroid auto-antibodies to thyroid peroxidase in these people to exclude autoimmune thyroiditis. Objectives: This study was undertaken to know the prevalence of hypothyroidism and its association with Anti-TPO antibody among adult sea food consuming population. Materials and Methods: A hospital-based cross-sectional study involving 300 patients was conducted in the Department of General surgery, Dr.SMCSI Medical College, Karakonam,Trivandrum during December 2012 to January 2014. Patients data collected, the relevant laboratory test(serum FT3, FT4 and Thyroid Stimulating Hormone [TSH]) done. Thyroid abnormalities were diagnosed on the basis of these laboratory results.Anti TPO antibody was estimated in those patients with hypothyroidism(High TSH) using Calbiotech Thyroid Peroxidase (TPO) IgG ELISA Kit. Results: Totally 30.4% of subjects had thyroid dysfunction, prevalence of hypothyroidism and subclinical hypothyroidism was 11.7 % and 15% respectively. Anti TPO antibody was positive in 71.4 % hypothyroid patients and 68.9 % subclinical hypothyroid patients. TSH had a significant positive correlation (r = 0.324, p=0.003) with anti TPO. There was a significant relation between hypothyroidism and Anti TPO Antibody suggesting thyroid autoimmunity as a risk factor for hypothyroidism. Conclusion: Significant relation between hypothyroidism and Anti TPO Antibody was found, suggesting thyroid autoimmunity as a risk factor for hypothyroidism.Autoimmune thyroiditis can be considered as one of the etiological factors for hypothyroidism in our population. But Iodine status or autoimmunity do not explain all thyroid dysfunction .Hence further studies are required to address these problems.
Authors and Affiliations
Thomas Cyriac, Peter Manoharan Chellappa, Sinnet P. R. , Anish Immanuel
Keywords
Related Articles
- EP ID EP354971
- DOI 10.7439/ijbar.v6i9.2480
- Views 74
- Downloads 0
Prevalence of Allergic Broncho Pulmonary Aspergillosis in patients with Asthma attending allergy clinic in a North West Indian Tertiary Care Institute
Context: Allergic Broncho Pulmonary Aspergillosis (ABPA) is an allergic disorder. Aspergillus fumigatus is the most common pathogen responsible for occurrence of ABPA. There can be serious consequences of ABPA including...
Study of Endometrial Pathology in Abnormal Uterine Bleeding
Objectives: To evaluate histopathology of endometrium in patients presenting with abnormal uterine bleeding and to find out the prevalence of various pathological conditions in endometrium in different age groups. Metho...
Histopathology of soft tissue tumors in association with immunohistochemistry
Aim: To study the histopathological pattern for understanding the classification and type of soft tissue tumors. To find out the relative incidence of benign and malignant soft tissue tumors and to classify the soft tiss...
Ulcerprotective activity of ethanolic extract of baccaurea ramiflora and Microcos paniculata on experimental animals
The current study was planned to evaluate the ulcer protective activity of the leaves of Baccaurea ramiflora and Microcos paniculata. Dried and crushed leaves of Baccaurea ramiflora and Microcos paniculata were defatted...
Evaluation of BCG Vaccine in Excessive Dermal Reactivity Test
BCG vaccine has been in use globally to control the tuberculosis since the year 1921 and there has been significant achievement to curtail the disease. The important tests as per pharmacopoeial requirements including cou...