Prevalence of hypothyroidism and its association with anti-thyroid peroxidase antibody among adult sea food consuming population attending a tertiary health care centre in Kerala
Journal Title: International Journal of Biomedical and Advance Research - Year 2015, Vol 6, Issue 9
Abstract
Background: Thereis less data on the prevalence of hypothyroidism in adult population of India. Currently with iodine supplementation and availability of iodine rich nutritious food,the iodine deficiency etiology in hypothyroidism is no more applicable. So it is useful to estimate thyroid auto-antibodies to thyroid peroxidase in these people to exclude autoimmune thyroiditis. Objectives: This study was undertaken to know the prevalence of hypothyroidism and its association with Anti-TPO antibody among adult sea food consuming population. Materials and Methods: A hospital-based cross-sectional study involving 300 patients was conducted in the Department of General surgery, Dr.SMCSI Medical College, Karakonam,Trivandrum during December 2012 to January 2014. Patients data collected, the relevant laboratory test(serum FT3, FT4 and Thyroid Stimulating Hormone [TSH]) done. Thyroid abnormalities were diagnosed on the basis of these laboratory results.Anti TPO antibody was estimated in those patients with hypothyroidism(High TSH) using Calbiotech Thyroid Peroxidase (TPO) IgG ELISA Kit. Results: Totally 30.4% of subjects had thyroid dysfunction, prevalence of hypothyroidism and subclinical hypothyroidism was 11.7 % and 15% respectively. Anti TPO antibody was positive in 71.4 % hypothyroid patients and 68.9 % subclinical hypothyroid patients. TSH had a significant positive correlation (r = 0.324, p=0.003) with anti TPO. There was a significant relation between hypothyroidism and Anti TPO Antibody suggesting thyroid autoimmunity as a risk factor for hypothyroidism. Conclusion: Significant relation between hypothyroidism and Anti TPO Antibody was found, suggesting thyroid autoimmunity as a risk factor for hypothyroidism.Autoimmune thyroiditis can be considered as one of the etiological factors for hypothyroidism in our population. But Iodine status or autoimmunity do not explain all thyroid dysfunction .Hence further studies are required to address these problems.
Authors and Affiliations
Thomas Cyriac, Peter Manoharan Chellappa, Sinnet P. R. , Anish Immanuel
Keywords
Related Articles
- EP ID EP354971
- DOI 10.7439/ijbar.v6i9.2480
- Views 89
- Downloads 0
Socio-demographic determinants associated with iron deficiency anemia in pregnancy in rural population of central India
Worldwide Iron deficiency anemia (IDA) affects 25% of the population and in India it affects 80% of pregnant women. A prospective observational study was conducted to know the relationship between IDA and socio-demograph...
A prospective observational study to predict difficult intubation using simple non-invasive tests
Introduction: Airway assessment is the first step in successful airway management. Several anatomical and functional maneuvers can be performed to estimate the difficulty of endotracheal intubation. We aimed to elucidate...
Hypolipidemic Activity of of Madhuca longifolia in Triton Induced Hyperlipidemic Rats
Objective:In the present study, an aqueous extract from Madhuca longifolia bark was evaluated for its hypocholesterolaemic and hypotriglyceridaemic activities using Triton WR-1339 induced hyperlipemic rats as experimenta...
Effect of isometric hand grip on heart rate in normotensive and hypertensive individuals during head up tilt (300 and 600)
Objective: To study the effect of isometric hand grip exercise at 20% on normotensive, treated hypertensive, and non treated hypertensive in supine position, and at 300 and 600 head up tilt. Material and Methods: After...
Immunomodulatory Potential Of Rutin And Quercetin In Swiss Mice Exposed To Gamma Radiation
Radioprotective mechanisms of Rutin (RUT) and Quercetin (QRT) against gamma radiation was studied by investigating recovery of endogenous spleen colony-forming units, haematological alterations in peripheral blood in Swi...