Prevalence of lung carcinomas in a tertiary care center and correlation with clinicopathological parameters
Journal Title: Medpulse International Journal of Pathology - Year 2019, Vol 10, Issue 3
Abstract
Background:worldwidepresently Lung cancer is the most common malignant disease (12.34% of all cancers) and the leading cause of cancer deaths (17.8% of all cancer deaths Aims and Objectives:To study prevalence of lung carcinomas in a tertiary care center and correlation with clinic pathological parameters. Methodology:This was a cross-sectional study of the lung carcinomas diagnosed in the Department of Pathology, Sri Ramachandra University from January 2009 to December 2013 were retrieved from the archives of the department. Paraffin blocks of all the cases ofNSCLC reported between 2009 and 2013 were retrieved from the Archives of the Pathology Department of Sri Ramachandra Medical College and were included in the study. The statistical analysis was done by SPSS 19 version software.Result:In our study we have seen A total of 111 lung carcinoma cases for which IHC subtyping was done, were identified and studied. Out of these cases there were 106 (95%) cases of NSCLC, and 5 (5%)cases of SCLC,Of the 106 cases of NSCLC 75 cases( 71% )were immunohistochemically proven primary adenocarcinomas of the lung, followed by SCC which constituted 27 cases(25%),and Non-Small cell carcinoma other subtypes constituted 4 cases( 4 % ). The majority of the patients were in the age group of61-70i.e. 42.67% , followed by 51-60were 25.33%, 71-80were12%,41-50were 10.67%, 81-90 were 5.33 %, 31-40 -4%.Maximum number of cases was in the 6th decade, in which males were the most commonly affectedbut the difference is not statistically significant (X2 =3.104,df=5, p=0.683). In our study 57% of the cases had lesion in the upper lobe of lung. Sixty percent of the cases were located in the right lung and 36% of the cases were in the left lung and 4% cases were bilateral. In our study 64% of the cases were not associated with smoking.The most common histological subtype of lung adenocarcinoma in our study was moderately differentiated adenocarcinoma which constituted 46 % Lymph node metastasis was present in 31% of the cases, Distant metastasis was present in 15% of the cases. Conclusion:It can be concluded from our study that majority of cases of lung cancers were of NSCLC in that majority were adenocarcinomas , maximum cases found in the sixth decade of life, most common lobe affected was upper lobe , rightlung and majority of the patients associated with smoking The most common histological subtype of lung adenocarcinoma in our study was moderately differentiated adenocarcinoma and also there was associated metastasis like lymph node and distant.
Authors and Affiliations
Prema Devi E, C N Sai Shalini, D Prathiba
Keywords
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