Prevalence of metabolic syndrome amongst people with type 2 diabetes mellitus and its impacts on the occurrence of diabetic kidney disease
Journal Title: MRIMS Journal of Health Sciences - Year 2017, Vol 5, Issue 4
Abstract
Background: Prevalence of metabolic syndrome (MetS) amongst people with Type 2 diabetes mellitus (T2DM) is high. Though, diabetic kidney disease (DKD) is an increasingly important cause of morbidity and mortality worldwide, its association with MetS is not profoundly evaluated in Indian population. Objectives: We aim to assess the prevalence of MetS and evaluate the impact of MetS on the occurrence of DKD amongst people with T2DM. Methods: The demographic, anthropometry, blood pressure, lipids, CVD (based on ECG and history of CVD) and DKD (based on e-GFR < 60 ml/min/1.73 m2) data of 1037 T2DM was obtained. MetS was defined by NCEP ATP III guidelines. Association of DKD was evaluated with other variables including MetS and its components in terms of unadjusted OR. The Odds Ratios were adjusted by considering covariates like age, gender, duration of diabetes and HbA1c in the logistic regression model. Results: The prevalence of MetS was 86.98% (female-91.3%, male-84.5%), DKD 6.85% and CVD 13.5%. Waist circumference contributed the most to MetS (91.69%) followed by HDL-C (71.73%) and TG (63.08%). Age and duration of diabetes showed significant positive association in occurrence of DKD. OR for people with MetS to develop DKD was high in univariate and multivariate analysis, though statistically insignificant. T2DM with hypertension are at higher risk of DKD with OR 2.1957 [95% CI: 1.1618, 4.1496] versus those without hypertension (p = 0.0154). Conclusion: Indian people with T2DM have high prevalence of MetS, where waist and low HDL-cholesterol are major contributors. MetS insignificantly, while hypertension significantly increases the risk of DKD in people with T2DM having MetS.
Authors and Affiliations
Gupta KS, Vali SA
Keywords
Related Articles
- EP ID EP423064
- DOI -
- Views 118
- Downloads 0
A comparative study of mycobacteria detected by BACTEC method and LJ medium
Background: Tuberculous pleural effusion has been known to phuysicians since antiquity, having been well des ribed by Hippocrates and Celsus. Involvement of the pleural surfaces in patients with tuberculosis is still one...
Screening of Newly Synthesized Benzofuran [3-2, d] Pyrimidine Derivatives for Anti Inflammatory Activity
Background: Most of the non steroidal anti-inflammatory drugs are not equally effective in all inflammatory conditions especially in chronic conditions like rheumatoid arthritis, osteoarthritis and ankylosing spondylitis...
A Comparative Study of Fetal Malpresentations in Scarred and Unscarred Uteri
Background: Malpresentations and malpositions as such are associated with increased incidence of adverse feto-maternal outcomes when compared to cephalic vertex presentations. Scarred uterus predisposes to malpresen...
Correlation between cytology and histology in cervical lesions
Background: Cervical cancer is the most common gynecological cancer in India. It is only cancer which can be detected in the pre-cancerous state by Pap smear cytology. Objective: To study correlation between cytology an...
Assessment of erythrocyte SOD activity in different stages of Essential Hypertension patients
Oxidative stress has been found to be associated with most of the diseases. In the past several years, much interest has arisen over the involvement of free radical metabolism in the disturbance in endothelial or intimal...