PREVALENCE OF MOLECULAR SUBTYPES OF CARCINOMA OF BREAST- A STUDY FROM NORTH INDIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 89
Abstract
BACKGROUND Carcinoma breast is a heterogenous disorder with varying clinical course and survival rates in same grade and stage of patients. Therefore, there is a need of classification system of carcinoma breast wherein the patients with similar clinical course and survival rates can be clubbed together in a subgroup. Molecular classification divides carcinoma into four categories based on ER/PR/HER2/neu expression: ER+ and⁄or PR+ and HER-2/neu− (Luminal A), ER+ and⁄or PR+ and HER-2/neu+ (Luminal B), ER− and⁄or PR− and HER-2/neu+ (HER-2/neu overexpressing), ER−, PR− and HER-2/neu− (Triple negative/Basal like). This classification has prognostic and predictive value and allows personalised, molecular targeted therapy. There is a geographical difference in the prevalence of these molecular subtypes, similar to the incidence of carcinoma breast. The aim of our study is to classify and define precisely the prevalence of molecular subtypes of carcinoma breast in our population using ER, PR and HER-2/neu immunohistochemistry on formalin-fixed paraffin-embedded blocks and to correlate these subtypes with histological and clinical features. The objective of our study is to evaluate the prevalence of molecular subtypes of carcinoma breast in our Population. MATERIALS AND METHODS It was an observational study wherein all cases of carcinoma breast from January 2010 to Dec. 2016 were retrieved, reviewed, graded and staged according to the 2003 WHO histological classification of breast tumours. Immunohistochemistry was for oestrogen receptor (ER), progesterone receptor (PR) and HER-2/neu was done in those cases where there was clinical requisition. Statistical analysis and correlation among categorical variables in the univariate analysis were determined using the Pearson-ChiSquare test. Significance was assumed at p –value less than 0.05. RESULTS Of total 40 cases, ER was positive in 22, PR in in 18 and HER-2 in 12. Molecular subtypes were: Luminal A: 35% (14/40), Luminal B: 22.5 (9/40), HER-2/neu group: 30 % (12/40) and Triple negative group: 12.5 (5/40). CONCLUSION The carcinoma breast is a heterogenous disorder clinically, morphologically and molecularly. Increasing number of molecular subtypes are being described which have prognostic and predictive value. Thus, emerging evidence shows promise that traditional classification of carcinoma breast can be supplemented with molecular classification for specialised, personalised and molecular targeted therapy
Authors and Affiliations
Surinder Kumar Atri, Virender Mohan Rana, Minakeshi Rana, Zahoor Ahmed
Keywords
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- EP ID EP277951
- DOI 10.14260/jemds/2017/1349
- Views 92
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