PREVALENCE OF PRIMARY DRUG RESISTANCE TO RIFAMPICIN AND ISONIAZID IN NEWLY DIAGNOSED SPUTUM SMEAR POSITIVE PULMONARY TUBERCULOSIS
Journal Title: INTERNATIONAL JOURNAL OF ADVANCED MEDICINE - Year 2019, Vol 3, Issue 5
Abstract
Aims and objective: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients. Material and method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA). Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone. Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used for the detection of primary drug resistance in sputum smear positive TB patients.
Authors and Affiliations
Ashok Kumar, Jawahar Lal Joshi, Abdurazack Umathoor, Vishal Chopra, Komaldeep Kaur, Vidhu Mittal
Keywords
Related Articles
- EP ID EP638985
- DOI -
- Views 44
- Downloads 0
CLINICAL PROFILE OF HOSPITALIZED CHILDREN WITH FEBRILE SEIZURES
Objective: The objectives of this study were to evaluate the clinical prole, investigations, course in hospital and outcome of children admitted with febrile seizures. Methods: 70 children with febrile seizures were tak...
A STUDY OF ETIOLOGICAL FACTORS AND CO-MORBIDITIES ASSOCIATED WITH CEREBRAL PALSY
INTRODUCTION: Cerebral palsy is a diagnostic term used to describe a group of permanent disorders of movement and posture which cause activity limitation, that are attributed to non-progressive disturbances in the develo...
EFFECT OF NUTRITIONAL STATUS AT THE TIME OF INITIAL PRESENTATION ON OUTCOME IN CRITICALLY ILL PATIENTS ADMITTED TO ACUTE MEDICAL CARE UNIT: A PROSPECTIVE STUDY
BACKGROUND: Malnutrition is evident in40 to 80 % critically ill patients. As nutritional assessment is not routinely done malnutrition remains undiagnosed in nearly 70% ICU patients.
PREVALENCE AND ASSOCIATED RISK FACTORS OF BOVINE TUBERCULOSIS IN MECHA DISTRICT, NORTHWESTERN AMHARA, ETHIOPIA.
Background: Bovine tuberculosis, which is caused by Mycobacterium bovis, is a chronic debilitating disease of animals characterized by the formation of granulomas (tubercles) in tissues and organs. Aim: This study aimed...
VALIDATION OF URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, INTERLEUKIN-18 AND KIDNEY INJURY MOLOCULE-1 IN THE DIAGNOSIS OF HEPATORENAL SYNDROME IN EGYPTIAN PATIENTS WITH HEPATITIS C VIRUS- RELA
Hepatorenal syndrome (HRS) is a functional and potentially reversible form of AKI that occurs in cirrhosis patients with ascites caused by splanchnic vasodilatation , cardiovascular dysfunction and renal hypo-perfusion;...