Prevalence of pulmonary hypertension in systemic sclerosis and it’s correlation with clinical variables
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction: Development of pulmonary artery hypertension (PAH) worsens prognosis of systemic sclerosis (SSc) and can be either isolated precapillary PAH or secondary to interstitial lung disease (ILD). Early diagnosis is of crucial importance. There is scarcity of data on PAH in patients with SSc in India. Objectives: To determine the prevalence and clinical correlates of PAH in systemic sclerosis using noninvasive cardiopulmonary evaluation and in selected cases by cardiac catheterization. Materials And Methods: Clinical and functional characteristics of 100 patients of systemic sclerosis were studied and they were evaluated by echocardiography to detect pulmonary artery hypertension. Our objective was to study the prevalence and the clinical correlation of PAH in SSc Results: PAH was found in 29% patients on echocardiography. Prevalence tend to increase with age of onset and duration of disease. However, it did not differ significantly between patients with limited cutaneous SSc (lcSSc) and patients with diffuse cutaneous SSc (dcSSc). On binary logistic regression analysis, none of the studied variables had any independent influence on development of PAH. Conclusion: PAH in SSc occurs in a remarkable proportion (29%) of patients without any ominous signs in early stages. Non-invasive screening of patients with SSc for PAH will help in early diagnosis and appropriate timely therapeutic intervention before significant end-organ damage occurs.
Authors and Affiliations
DR. Bhuban Majhi, DR. Nandita Pal
Keywords
Related Articles
- EP ID EP257847
- DOI 10.9790/0853-1609109095
- Views 51
- Downloads 0
A Comparative Study of Morphological Variation in Maxillary Lateral Incisor in North and South Indian Population
Objective: The objective of this study is to assess the morphological variation of maxillary lateral incisor among the North and South Indian population. Methods: 50 casts each from North and South Indian population was...
Glycemic Control And Raised Adenosine Deaminase Activity In Type 2 Diabetes Mellitus
Background: Metabolic disturbance and immunological imbalance are the key factors in the pathogenesis of Type 2 Diabetes Mellitus. In the present study we measured Plasma Adenosine Deaminase (ADA) activity, a marker of c...
Changing Etiological Incidence of Acute Pancreatitis in AdultsSingle Tertiary Centre Study.
Background: Acute pancreatitis is an inflamatory disease of pancreas having mild self limiting course of illness in 80% to mortality upto 20% of cases.In developed countries,most common causes of acute pancreatitis are c...
Evaluation of Role of Transvaginal Sonography as Diagnostic Aid in Comparison with Hysteroscopy in Management of Perimenopausal AUB
Background: Hysteroscopic guided biopsy is the gold standard for diagnosing endometrial pathologies. It is an invasive procedure and its use can be restricted by using imaging modalities like TVS. TVS is a first line scr...
A Comparative Study of Hernioplasty Done Under Local And Spinal Anaesthesia in A Tertiary Care Centre
Background: Surgical repair of inguinal hernia is one of the most commonly performed operations in general surgery worldwide. Hernia repair is commonly done under general or spinal anaesthesia but the advent of day care...