Prevalence of Rh phenotype in voluntary blood donors of Uttrakhand
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Karl Landsteiner and Wiener discovered Rhesus (Rh) system in the year 1940. Due to its immunogenicity along with A, B antigens, Rh D antigen testing was made mandatory in pre-transfusion testing. Presently there are more than 50 antigens in Rh blood group system but major ones are D, C, E, c, and e. The most important irregular red blood cell alloantibodies in daily transfusion practice are directed towards the Rh(antiD, -C, -E, -c and -e), KEL Therefore it is important to match the rare antigens before issuing blood so as to prevent complications. Our study aims to find out the Rh phenotype among the voluntary blood donors of Uttarakhand.This is a prospective cross-sectional study was carried out on 500 healthy voluntary blood donors from January 2016 to July 2017 at our blood bank. Donors were grouped and typed for ABO and Rh major antigens using monoclonal blood grouping reagents and statistical analysis was carried out. A total of 500 blood samples from voluntary blood donors were phenotyped. Among Rh antigens, Rhe was the most common antigen (98.2%), followed by RhD-94.2%, RhC-88.6%, Rhc-54.8% and RhE-18.6% with DCe/DCe (36.2%) being the most common phenotype and the least common phenotype is dce/dce and dCE/dCE (0.2%). Database for antigen frequency of Rh blood group system in local donors helps to provide antigen negative blood to patients and thereby improve blood safety.
Authors and Affiliations
Dr Ishani Gupta, Dr Rajnish Kumar, Dr Aparna Bhardawaj, Dr Gaurav Raturi
Keywords
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- EP ID EP374611
- DOI 10.9790/0853-1705063741.
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