Prevalence of Rifampicin resistance in newly diagnosed and previously treated cases of pulmonary tuberculosis by Xpert MTB / RIF assay
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 5
Abstract
Objective: • To determine the prevalence of Rifampicin resistance in new and previously treated PTB • To compare Rifampicin resistance obtained by Xpert and proportion method • To determine the prevalence of Isoniazid mono-resistance by proportion method Design: is cross-sectional study was carried over a period of one year (January - December 2015). Results: In 100 new TB suspects, smear positivity was 21% and culture positivity was 49%. Xpert assay detected MTB in 46% cases. In 100 previously treated cases, smear positivity was 40% and culture as well as Xpert MTB/RIF assay positivity was 47%. Xpert MTB/RIF assay has a sensitivity of 93.75% and specificity of 97.11% as compared to culture. Six (12.24%) Rifampicin resistant cases were observed in new TB cases & 19 (40.42%) in previously treated cases. All Rifampicin resistant cases were Isoniazid resistant also. INH mono-resistance was observed in nine cases. Conclusion: Rifampicin resistance, a surrogate marker of MDR-TB is more prevalent in previously treated cases. Xpert MTB/RIF assay provide the muchneeded diagnostic capacity for effective identification of MDR TB cases in lesser time.
Authors and Affiliations
Dr. Badrunnesa Khatun, Dr. Swapna Kanade, Dr. Gita Nataraj, Dr. Preeti Mehta
Keywords
Related Articles
- EP ID EP333397
- DOI -
- Views 82
- Downloads 1
IMPLEMENTATION AND ADMINISTRATION OF SARVA SHIKSHA ABHIYAN AND GROWTH OF ELEMENTARY EDUCATION – A STUDY OF KEONJHAR DISTRICT IN ODISHA
The Sarva Shiksha Abhiyan was launched 2001 as flagship programme to give a boost to universal primary education. The main focus of the scheme was to increase enrolment, attendance and to reduce drop-outs among the prima...
STUDY OF EPIDEMIOLOGY OF HAND SURGERY CASES IN INDIAN SCENARIO
PURPOSE: - To study the epidemiology of hand surgery cases in Indian scenario. METHODS: - Retrospective study of hand surgery cases operated in the year 2015-2016 at a tertiary centre in India and the cases were further...
SELLAR/SUPRASELLAR GERMINOMA MASQUERADING AS PITUITARY ADENOMA
We report a case of sellar/suprasellar germinoma in a 17-year-old female which was misdiagnosed as pituitary adenoma both clinically and on imaging. Patient presented with severe headache of short duration and diminished...
Study of Serum Paraoxonase Levels in Type 2 Diabetes Mellitus Patients & Suggests Risk of Cardiovascular Disease
Background and Objectives: Diabetes, a lifelong progressive disease, with metabolic dysregulation, is associated with increased risk of cardiovascular complications. Paraoxonase (PON), an enzyme associated with high-dens...
Haematological Profile in Chronically Undernourished Thrifty Rats at 28 Days of Age
Foetal programming due to undernutrition is a known risk factor for the worldwide epidemic of Type 2 diabetes and cardiovascular disease.Total leukocyte count (6.9 vs. 12.7x 103/μL ; p<0.0001, n=6, U vs. C) and Lymphocyt...