Prevalence of Rifampicin resistance in newly diagnosed and previously treated cases of pulmonary tuberculosis by Xpert MTB / RIF assay
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 5
Abstract
Objective: • To determine the prevalence of Rifampicin resistance in new and previously treated PTB • To compare Rifampicin resistance obtained by Xpert and proportion method • To determine the prevalence of Isoniazid mono-resistance by proportion method Design: is cross-sectional study was carried over a period of one year (January - December 2015). Results: In 100 new TB suspects, smear positivity was 21% and culture positivity was 49%. Xpert assay detected MTB in 46% cases. In 100 previously treated cases, smear positivity was 40% and culture as well as Xpert MTB/RIF assay positivity was 47%. Xpert MTB/RIF assay has a sensitivity of 93.75% and specificity of 97.11% as compared to culture. Six (12.24%) Rifampicin resistant cases were observed in new TB cases & 19 (40.42%) in previously treated cases. All Rifampicin resistant cases were Isoniazid resistant also. INH mono-resistance was observed in nine cases. Conclusion: Rifampicin resistance, a surrogate marker of MDR-TB is more prevalent in previously treated cases. Xpert MTB/RIF assay provide the muchneeded diagnostic capacity for effective identification of MDR TB cases in lesser time.
Authors and Affiliations
Dr. Badrunnesa Khatun, Dr. Swapna Kanade, Dr. Gita Nataraj, Dr. Preeti Mehta
Keywords
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