Prevalence of risk factor for Klebsiella pneumoniae carbapenemic-resistant in-fection in adults in a fourth level hospital, Bogota.
Journal Title: Revista Cuarzo - Year 2018, Vol 24, Issue 2
Abstract
Introduction: Gram-negative infections acquired in the hospital are an important cause of death, Klebsiella pneumoniae is one of the most significant bacteria, it is also related to the appearance of new mechanisms of antibiotic resistance. The carbapenems have allowed to fight certain of these resistant strains, however, the appearance of some with resistance to these antibiotics represents a therapeutic challenge. From this clinical context, it was proposed this research, to establish the prevalence of risk factors in adult patients with isolates of Klebsiella pneumoniae resistant to carbapenems. Material and methods: A retrospective descriptive study was carried out in the San Rafael Clinical University Hospital of Bogotá (Colombia). - Selection of patients: From 295 reviewed clinical records of patients hospitalized with positive isolation for Klebsiella pneumo-niae with carbapenemic resistance profile confirmed, in the period January 2013 to December 2015, 84 patients were obtained who fulfilled all the inclusion criteria. - Measurements: Demographic variables such as sex and age were taken into account, as well as the different conditions probably associated with the infectious condition. - Analytical methods: Qualitative variables were calculated absolute and relative frequencies, and quantitative variables measures of central tendency and dispersion were calculated. Results: Of 84 patients, 55% corresponded to females, had a mean age of 66 years. The microbiological isolation in urine was 30.4%, in blood 24.3%, peritoneal fluid 20.7% and tracheal secretion 12.1%. 91.6% of the population had hospitalization in the last 3 months, 86.5% received antibiotic treatment during hospitalization, of these 59.1% was Meropenem, 26.2% was Ampicillin Sul-bactam, 23.9% was Vancomycin, 18.3% was Piperacillin Tazobactam. 54.7% underwent some surgical procedure 3 months before the isolation, of which 47.8% corresponded to abdominal surgeries and 13.1% to thoracic surgery, then they appeared orthopedic surgery, in central nervous system and gynecological. 70% of the cases had antecedents of implantation of intravascular devices, 45.2% exposure to mechanical ventilation, 24% use of parenteral nutrition. Conclusions: This research establishes the bases to propose new researches that propose prevention strategies with the objective of reducing the chances of acquiring this multiresistant infection.
Authors and Affiliations
Solorzano, C. , Saavedra, C. , López, V. , Linares, P. , Romero, P. , Mora, J. , & Ovalle, A.
Keywords
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- EP ID EP694631
- DOI https://doi.org/10.26752/cuarzo.v24.n2.349
- Views 139
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