Prevalence of Serological Markers of TORCH Infections in Biliary Atresia and Other Neonatal Cholestatic Disorders
Journal Title: Open Journal of Pediatrics and Child Health - Year 2016, Vol 2, Issue 1
Abstract
Background: Viral infections, congenitally or perinatally acquired, have been associated with neonatal cholestasis. Investigators have suggested a similar link to biliary atresia (BA). Aim: The aim of the current study is to investigate the prevalence of serological markers of congential infections in BA and other neonatal cholestatic disorders. Methods: This retrospective study included 94 patients with confirmed diagnosis of BA. A nearly comparable number of patients with cholestasis due to causes other than BA (n = 91) were also recruited and termed non-BA group. The data was retrieved from patients’ records. TORCH (toxoplasma, rubella, cytomegalovirus [CMV] and herpes simplex virus [HSV] type 1 and type 2) antibodies (immunoglobulin [Ig]M and IgG) were performed in all the patients using enzyme-linked immunosorbent assay. CMV DNA was detected by polymerase chain reaction (PCR).
Authors and Affiliations
Sira Mostafa Mohamed, Elhenawy Ibrahim A, Khalil Fatma Omar
Keywords
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- EP ID EP554311
- DOI 10.17352/2640-7612.000010
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