Retinoblastoma (RB) in Saudi Arabia- Retrospective Comparative Review of a Registry
Journal Title: Open Journal of Pediatrics and Child Health - Year 2015, Vol 1, Issue 1
Abstract
Purpose: Published data regarding retinoblastoma in Saudi Arabia (KSA) is sparse. The study will present comparison of clinical and pathologic features, and evolving patterns of the treatment during 1983-1997 (Early group=EG) to 1998-2012 (Late group=LG) periods from an RB registry representing all Rb cases in KSA. Methods: This health record review was conducted in 2014. From the RB registry, information about gender, age, clinical features and stage at presentation; laterality, regional distribution, history, co-morbid diseases, pathologic features, surgical treatment modality and treatment outcomes were collected. Results: The EG and LG group had 343 and 430 Rb patients respectively. The incidence of Rb in 1997 and in 2012 was 0.06 and 0.03 per 1,000 live births in Saudi Arabia respectively. The gender distribution was similar. The median age of presentation was 24 (range 11, 39) months in EG vs. 18 (8, 31) months in LG (p <0.001). Incidence of unilateral Rb was 58% [200/343] in EG vs. 56% [278/485] in LG. Positive family history of Rb was <10% in both groups. However, in EG, 120 (35%) parents were first cousins vs. 124 (27%) in the LG (p=0.12). Leukocoria was the most common presentation [71% (n=255) in EG and 66% (n=343) in LG].
Authors and Affiliations
Pirouzian Amir
Keywords
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- EP ID EP554288
- DOI 10.17352/2640-7612.000005
- Views 37
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