Prevalence of weak D antigen and Rh positive and Rh negative blood groups among blood donors - A Six year experience in a blood bank of tertiary health care centre of central India
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 6, Issue 1
Abstract
Background: After ABO group system, Rh D is clinically one of the most important blood group systems. Testing of all Rh negative units (by routine method) is must to detect weak D antigen by IAT method. When test show agglutination with anti D and D (u) it is labelled as Rh (D) positive. If test show no agglutination it is labelled as Rh (D) negative. Objectives: To know the Prevalence of weak D antigen (Du) and Rh positive and Rh negative blood groups in blood donors of blood bank of tertiary health care centre of Bhopal (M.P). Material and Method: Retrospective study among donors blood samples of Rh negative by immediate spin tube method were tested for weak D by indirect antiglobulin test (IAT) by tube method. Observation and Results: Among 11607 healthy blood donors, 11131(95.89%) were RhD factor positive while, 476(4.09%) were RhD negative. Out of 476 RhD factor negative donors 05(0.04%) were weak D positive. The study conducted on donors of Blood Bank of Peoples College of Medical Science and Research Centre Bhanpur Bhopal (M.P) from January 2012 to December 2017. Conclusion: According to many studies weak D antigen is immunogenic and is capable of producing alloimmunisation if transfused to RhD negative subjects so weak D detection prevent alloimmunisation in Rh negative patients.
Authors and Affiliations
Reetesh Kumar Gujar, Upasana Uniya, Deepika Kirar
Keywords
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