PREVALENCEOF EXTENDED SPECTRUM β LACTAMASES (ESBL) IN NON-FERMENTING GRAM NEGATIVE BACILLI FROM CLINICAL ISOLATES.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 2
Abstract
Background and Objectives: Non fermenting gram negative bacilli (NFGNB) producing Extended spectrum β lactamases (ESBL) are an increasing cause of concern in the hospitals as they produce a therapeutic dilemma for the treating physician. The present study was undertaken to know the prevalence of ESBL producing non fermenting gram negative bacilli from clinical isolates and their antibiotic resistance pattern. Methods: A total of 389 non fermenting gram negative bacilli were recovered from various clinical specimens. All the samples were processed for routine bacterial culture and antimicrobial susceptibility test as per standard protocol. They were further subjected to ESBL production detection by phenotypic confirmatory double disk diffusion test using ceftazidime with and without clavulanic acid. Results: A total of 199(51.15%) isolates were found to be Extended spectrum β-lactamase producers. Majority of Acinetobactercalcoaciticus-baumaniicomplex 80 (80.8%) were ESBL producer where as 114(41.6%) of Pseudomonas aeruginosaisolates were found to be ESBLproducers. ESBL producing organisms were more drug resistant compared to ESBL non producers; Conclusion: The prevalence of ESBL was 51.15% among NFGNB. Significantly higher resistance rate was observed by these isolates to almost all the drugs routinely used.
Authors and Affiliations
Thipperudraswamy . T*| Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital Chitradurga, Karnataka, India, Sudhindra. K. S| Associate Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, Shobha Nadigar| Professor and Head, Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India, Mahesh Kumar| Assocate Professor, Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
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