Priapism-Induced Remote Alterations on Liver Histology, Liver Biomarker Enzymes and Haematological Parameters of Animal Models and the Attenuating Role of Ascorbic Acid
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 1
Abstract
The remote effect of priapism on haematological indices and liver function is still obscured. We evaluated the reversal effect of vitamin C on remote changes in blood parameters and liver function of Sprague – Dawley rats. 25 male rats were randomly divided into 5 groups of 5 rats each. Group 1 served as the control and was treated with 5ml/kg body weight normal saline. Group 2 rats were induced with priapism. Group 3 was induced with priapism and then treated with 25 mg/kg body weight of vitamin C. Group 4 was induced with priapism and then treated with 2.5mg/kg body weight of testosterone. Group 5 was induced with priapism but were treated with both vitamin C and testosterone. Priapism was induced for one week followed by 6 hours post priapism administration of testosterone and vitamin C. Results showed markedly elevated liver enzymes in treated groups especially in groups 2 and 4. The haematological indices also revealed anaemia and leucopaenia in various treated groups. Although the role of both testosterone and Vitamin C was evaluated, only vitamin C treated groups showed improvement in blood parameters and liver function of Sprague-Dawley rats.
Authors and Affiliations
Igwe O, Akunna G. G, Oremosu A. A. , Gbotolorun S. C. , Aniah J. A. , Inyang B
Keywords
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