Primary antibody deficiencies in adults: A contemporary clinical approach
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2013, Vol 30, Issue 4
Abstract
Primary antibody deficiencies (PADs) are no longer considered rare diseases. Given that about half of these disorders are diagnosed in adult life with a 5-year delay, while at death the median age of patients is above the 50th year of life, PADs represent a common and challenging problem for the adult medicine. The vast majority of patients requiring medical care for PADs during adult life suffer from common variable immunodeficiency (CVID). This is a review of adult-onset PADs focusing on their as yet unexplained inflammatory and lymphohyperplastic manifestations, which dominate the clinical picture of CVID, especially after effective management of infections and their complications by intravenous immunoglobulin treatment. The proposed classifications of CVID are presented which address both the clinical and the pathogenetic aspects of the disease. These classifications and the surrogate immunophenotype markers might be helpful for the early identification of patients with PADs, particularly those presenting with granulomatous disease and/or lymphadenopathy that are not easily detectable. The criteria for and specific differential diagnostic aspects of CVID in adult patients are reviewed, and the effectiveness of immunoglobulin therapy as assessed 30 years after its first introduction is evaluated.
Authors and Affiliations
M. SPELETAS, A. GERMENIS
Keywords
Related Articles
- EP ID EP87626
- DOI -
- Views 72
- Downloads 0
Association of fibrinogen α-chain polymorphisms with coronary atherosclerosis and plasma fibrinogen concentration
OBJECTIVE To identify genetic susceptibility to coronary artery disease (CAD), associated with fibrinogen α-chain (FGA) single nucleotide polymorphisms (SNPs). METHOD A prospective, genetic association study was perfo...
Ανασκόπηση των σημαντικότερων μελετών πρωτοπαθούς και δευτεροπαθούς πρόληψης αιφνίδιου καρδιακού θανάτου στη στεφανιαία νόσο και την καρδιακή ανεπάρκεια
Οι ασθενείς υψηλού κινδύνου για αιφνίδιο καρδιακό θάνατο (ΑΚΘ), οι οποίοι δεν είχαν καταγραμμένα επεισόδια εμμένουσας κοιλιακής ταχυκαρδίας ή κοιλιακής μαρμαρυγής, αλλά εμφανίζουν δυσλειτουργία αριστερής κοιλίας και ασυμ...
The usefulness of point-of-care testing for diagnosis in cases suspicious for swine flu
No abstarct available
The relationship of serum ferritin level with cardiovascular risk factors in healthy men
OBJECTIVE The role of ferritin as a marker of inflammation in the clinical assessment of cardiovascular risk remains to be determined. The purpose of this study was to assess correlations between serum ferritin levels an...
Normative values for physical fitness of Greek boys and girls aged 6–18 years
OBJECTIVE To establish updated normative values of physical fitness in Greek children aged 6 to 18 years for the following measures: 20 m shuttle run, standing long jump, sit-and-reach, 10×5 m shuttle run and sit-ups, an...