Prodrugs and soft drugs.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 5
Abstract
This review focuses on a new approach to the development of drugs, namely on prodrugs and soft drugs. Nowadays, we try to design drugs that heal sick people having the best acceptance of patients. They must be efficient and selective on their site of action and must be metabolized to non-toxic derivatives. Both, prodrugs and soft drugs should have good distributive properties to enhance their quality. They are designed to maximize the amount of an active drug that reaches its target, through changing the physicochemical, biopharmaceutical or pharmacokinetic properties of drugs. Prodrugs are changed into the active drug within the body through enzymatic or non-enzymatic reactions. Soft drugs are novel and active analogues of already known therapeutic agents. It is expected that continued studies will improve drug properties so as to achieve the best drug delivery system.
Authors and Affiliations
Andrzej Stańczak, Anna Ferra
Keywords
Related Articles
- EP ID EP128821
- DOI -
- Views 102
- Downloads 0
Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention.
Liver X receptor (LXR) alpha and beta are ligand-activated transcription factors that regulate the expression of genes involved in the removal of cholesterol from cells by high-density lipoproteins, the transport of chol...
Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics.
Target controlled infusion (TCI) devices are increasingly used in clinical practice. These devices unquestionably aid optimization of drug dosage. However, it still remains to be determined if they sufficiently address d...
New derivative of staphylokinase SAK-RGD-K2-Hirul exerts thrombolytic effects in the arterial thrombosis model in rats.
SAK-RGD-K2-Hir and SAK-RGD-K2-Hirul are recombinant proteins that are derivatives of r-SAK (recombinant staphylokinase). They are characterized by their fibrin-specific plasminogen activation properties and their antithr...
Amifostine improves hemodynamic parameters in doxorubicin-pretreated rabbits.
Amifostine reduces nephrotoxicity and myelotoxicity of alkylating agents. Little is known about its role in preventing cardiotoxicity. We studied if amifostine could affect the hemodynamic parameters in doxorubicin-pretr...
Association studies of 5-HT(2A) and 5-HT(2C) serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients.
Lithium is one of the most commonly used drugs in the prophylaxis and treatment of bipolar disorder. The mechanisms of mood stabilization by lithium incorporate its effect on serotonergic neurotransmission. This paper in...