Profile of fever with Pancytopenia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Background: Pancytopenia is defined as presence of anemia, leucopenia and thrombocytopenia and it results from a number of disease processes. Aim:This study was carried out to investigate for and to identify the causes of pancytopenia, to find out the frequency of different causes especially fever and to determine the incidence of pancytopenia in relation to sex and age. Methods:This study was conducted in the Department of Pathology, Siddhartha Medical College, Vijayawada over a period of two years (October 2015 to November 2017). All the patients referred to the clinical laboratory for routine complete blood count and peripheral smear examination from both the outpatient and the inpatient departments, were screened for pancytopenia. 250 cases that fulfilled the diagnostic criteria were selected. Detailed hematological investigations were performed according to standard methods to ascertain the causes of pancytopenia. Bone marrow aspiration was done wherever indicated. Results: A definite male preponderance was observed, the male to female ratio being 1.4:1. The majority of cases were encountered in 3rd and 4th decades. Infections (77.2%), Anaemias (17.6%), malignancies (3.6%), Drug induced (0.8%) and Idiopathic thrombocytopenic purpura (ITP 0.8%) were the four most common causes. Conclusion:As a large proportion of causes for pancytopenia are treatable and reversible, accurate diagnoses and timely intervention maybe lifesaving and will certainly have impact on the morbidity and mortality in these vulnerable patients. Knowing the exact etiology is thus important for specific and timely treatment and for prognostication
Authors and Affiliations
Dr. D. Kalyani, Dr. R. Sasank
Keywords
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- EP ID EP250782
- DOI 10.9790/0853-1612061620
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