Profile of Neonatal Seizures and its Correlation with Serum Sodium Levels: A Prospective Cross-sectional Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 4
Abstract
ABSTRACT Introduction: Neonatal seizures have detrimental effect on the immature developing, neonatal brain despite aetiological factors. Also, they can denote systemic diseases or altered biochemical milieu. Maintaining electrolyte balance is vital to the functioning of central nervous system and has either direct or indirect impact on neuronal stability. Aim: To estimate the serum sodium levels in neonates presenting with seizures and to correlate the serum levels with clinical manifestations and to delineate its aetiological factors. Materials and Methods: It was a prospective cross-sectional study conducted on 76 neonates admitted in tertiary level care NICU with seizures and evaluated with detailed history and clinical examination. They were subjected to serum sodium level estimation coupled with other relevant investigations to delineate the definitive aetiology. These parameters were recorded in a predesigned, pretested structured questionnaire and the obtained data was analysed statistically by Chi-square test using SPSS version 20. Results: Of the 76 neonates enrolled, 59.2% (n-45) neonates had hyponatremia, of them 17.7% (n-8) had severe hyponatremia. Drowsiness was significantly more frequent in hyponatremic neonates (p<0.001). Hyponatremia manifested more often among preterm neonates with statistical significance (p=0.020). Also, mortality was significantly high in neonates with hyponatremia (p=0.003). Similarly, hyponatremia was found to be significantly more frequent in neonates with Hypoxic Ischemic Encephalopathy (HIE) (p<0.001). Conclusion: Hyponatremia was manifested in 59.2% of the neonates with seizures. Severity and duration of hyponatremia is an important prognostic marker of neonatal seizures, so should be managed immediately.
Authors and Affiliations
Rachna Pasi, Banashree Roy, Kumar Satish Ravi, Swathi Chacham
Keywords
Related Articles
- EP ID EP553310
- DOI 10.7860/JCDR/2019/40485.12760
- Views 38
- Downloads 0
Study of Thalassemia and Case Series Haemoglobinopathies in Pokhara, Nepal
Introduction: Presence of thalassemias and haemoglobinopathies are described in some communities especially from Terai belt. However, there are no any population based studies done till date, including other parts of Nep...
Maternal Anaemia is a Risk Factor for Anaemia in Infants at 14-16 Weeks-Need for Early Initiation of Iron Supplementation
ABSTRACT Introduction: Exclusive Breast Feeding (EBF) is recommended uniformly for all infants till six months. It is believed that since bioavailability of iron in breastmilk is high this along with the fetal iron store...
Unusual Aetiology of Pasteurella canis Biovar 2 Causing Dacryocystitis in HIV Patient: A Case Report and Review of Literature
Pasteurella species are zoonotic bacterial pathogens implicated very infrequently in various human infections following animal bites or licks usually of dogs and cats. This case report described a rare clinical presentat...
Diagnosis of Acute Q Fever by Detection of Coxiella burnetii DNA using Real-Time PCR, Employing a Commercial Genesig Easy Kit
Introduction: Query (Q) fever is an important zoonosis and a cause of concern for humans, due to the potential bioterrorism threat posed by the causative agent, Coxiella burnetii. Because of the danger of contracting the...
Does Training of Sensory Processing Helps in Improving Motor Execution in Children with Cerebral Palsy?
Letter to Editor