Prognosis Comparison Molecular Subtype Breast Cancer between Young and Adult Women at General Hospital Dr. M Djamil Padang
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 6
Abstract
Breast cancer is a heterogenic disease with various biologic profiles and clinical prognosis. A research in Netherland by Esther, et al 2013, showed that molecular subtypes of breast cancer have different distribution and prognostic between young and adult, but there is no local and national data.A Comparative research with cross sectional design was Held in January-April 2015 with 96 samples of breast cancer women with age < 40 years old and > 40 years old, recorded in medical records and breast cancer registrated from 2012-2014. Young women Breast cancer at General Hospital Dr. M. Djamil Padang for 3 years (2012-2014) are 27.1% and the adult are 72.9%. In bivariate analysis, there are no relationship between characteristics of tumor with recurrent and death event while in the adult women breast cancer, tumor size and metastases have relation with recurrent and death event that are statistically significant. There are different characteristics and description of molecular subtype breast cancer between young and adult women, young ages are tend to have big tumor, lymph node positive, lympovascular invasion, high grade tumor, proliferation index Ki67 high and negative hormone receptor. There are different tendency of prognosis women breast cancer between young and adult based on molecular subtype but statistically, the relationship is not significant. Breast cancer is a heterogenic disease with various biological profile and clinical prognosis [1]. Most patients with breast cancer are old women, but we still lack of specific guideline about evidence based therapy for this age group. Population of Young woman with breast cancer, otherwise, has based the decision about breast cancer therapy on prognostic, predictive factors, and tumor characteristic [2]. The European Society of Breast Cancer Specialist defined young women as women aged less than 40 years [3]. There is favorable correlation between ages with biological characteristic of the tumor. Compared with young age, old aged patient with breast cancer had more diploid, low s-phase fraction, normal p53, negative or low epidermal growth factor receptor and c-erB2 [4]. Breast cancer in women aged under 40 years old tend to has larger size (tumor median is 2 cm in young age and 1.5 cm in old age), more advanced stadium when diagnosed (more likely with positive lymph gland) and more aggressive (less likely to have good differentiation), low expression of estrogen/progesterone receptor (ER/PR), high expression of human epidermal growth factor receptor2 (HER2), and Ki67 marker proliferation [5-10]. Tumor with positive hormone receptor has better outcome, where luminal A tumor has slower progressivity compared with luminal B tumor. While tumor with negative hormone receptor have aggressive natural pathogenesis and poor outcome [2]. Although it has been given the optimal treatmentt, but some clinical trials showed that breast cancer patient with young age had worse outcome compared with old aged breast cancer patient [10]. The distribution and prognostic effect of certain molecular subtype from old aged breast cancer patient compared to young aged breast cancer patient is remains unclear. A study conducted by Esther et al. [10] in Netherland showed that breast cancer molecular subtype has distribution and prognostic effect difference between old aged breast cancer patient compared to young aged breast cancer patient. While the data about comparison about distribution and breast cancer molecular subtype prognostic between young and old aged breast cancer patient, either local or nationwide, was not found by author. This is why author wanted to investigate thedifference of breast cancer molecular subtype prognostic between young and old aged breast cancer patient at Dr. M DjamilGeneral Hospital, Padang.
Authors and Affiliations
Azamris A, Irwan I, Hafni Bachtiar
Keywords
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- EP ID EP573901
- DOI 10.26717/BJSTR.2017.01.000508
- Views 141
- Downloads 0
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