Prognostic Evaluation of the Expression of HER-2/neu in Adenocarcinoma of the Uterine Cervix - An Original Study in a Tertiary Care Centre
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Background: Worldwide, cervical carcinoma is second only to breast carcinoma in its incidence and mortality. About 471,000 new cases are diagnosed every year, mainly among the economically disadvantaged in both developing and industrialized nations. Cancer of uterine cervix, the most prevalent cancers among the Indian females, is an important cause of morbidity and mortality among women . Adenocarcinoma currently comprises 10-25% of all cervical carcinomas. The overall survival rate for adenocarcinoma of cervix is worse than from the more common squamous cell carcinoma of the uterine cervix. Materials and methods: This study was conducted in the Department of Pathology, R.G.Kar Medical College and Hospital. It was cross-sectional observational study ,was done in the Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata. A total of 105 cases of cervical carcinoma cases were obtained during the period of January 2017 to June 2018.Out of 105 cases, 20 cases (19%)of Adenocarcinoma of cervix were diagnosed during this period. After confirming the diagnosis of Adenocarcinoma of Cervix histopathologically, sections were taken for immunohistochemical expression of HER-2/neu . Results were analysed at the end of the study. Results: HER-2/neu expression areas showed brown coloured membrane staining. Samples with Score 0 and 1+ were considered negative and those with scores 2+ and 3+ were considered positive. Out of 20 cases of adenocarcinoma of cervix ,7 cases(35%) show 1+ positivity, 5 cases (25%)show 2+ positivity, 6 cases(30%) show 3+ positivity. We found in our study that out of 20 cases of cervical adenocarcinoma, 11 cases (55%) were HER-2/neu positive , while rest 9 cases were HER-2/neu negative. In our present study, we noticed that intensity of HER-2/neu expression increased in tumour of higher grade ( Mod. Diff.> Well diff.). However, no statistically significant correlation (p=0.198) was established between the grade of Cervical Adenocarcinoma and Expression of HER-2/neu. Increased lymph node metastasis noted in moderately differentiated Adenocarcinoma cases (i.e. poor prognosis). Conclusion: This study shows the importance of continued basic and traditional research on the HER-2/neu receptors in invasive cervical carcinoma cases.The results of the present study indicate that evaluation of HER-2/neu expression may provide additional and independent prognostic information to predict the clinical course of cervical adenocarcinoma.
Authors and Affiliations
Dr. Tripti Das
Keywords
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